Personalized Brain Stimulation to Treat Chronic Concussive Symptoms

PHASE2Not yet recruitingINTERVENTIONAL
Enrollment

75

Participants

Timeline

Start Date

January 31, 2024

Primary Completion Date

July 31, 2025

Study Completion Date

January 31, 2026

Conditions
Post-Concussion SyndromeConcussion, BrainMild Traumatic Brain InjuryHead InjuryHeadacheDizzinessCognitive SymptomDysautonomiaAnxietyIrritability; SyndromeDepressionPost-traumatic Stress Disorder
Interventions
DEVICE

Active cTBS

600 active cTBS pulses will be delivered continuously (3 pulses at 50 hertz (Hz), repeated at 5 Hz, 15 pulses/sec, continuously for 40 seconds) twice/day for 1,200 pulses/day. The MagVenture MagPro active/sham system will be used to enable double blinding by universal serial bus (USB) key in which a current will be delivered through surface electrodes on the skin beneath the coil to mimic the sensory experience of cTBS for active and sham groups.

DEVICE

Inactive/Sham cTBS

600 inactive, or sham, cTBS pulses will be delivered continuously (3 pulses at 50 hertz (Hz), repeated at 5 Hz, 15 pulses/sec, continuously for 40 seconds) twice/day for 1,200 pulses/day. The MagVenture MagPro active/sham system will be used to enable double blinding by universal serial bus (USB) key in which a current will be delivered through surface electrodes on the skin beneath the coil to mimic the sensory experience of cTBS for active and sham groups.

BEHAVIORAL

Imaginal exposure

Personalized recordings about participants' descriptions of triggering or neutral stimuli or activities

Trial Locations (1)

90095

UCLA, Westwood, Los Angeles

All Listed Sponsors
collaborator

United States Department of Defense

FED

lead

University of California, Los Angeles

OTHER