PET and EBV DNA-directed Therapy for Localized Nasal Extranodal NK/T Cell Lymphoma

NARecruitingINTERVENTIONAL
Enrollment

89

Participants

Timeline

Start Date

December 6, 2023

Primary Completion Date

October 31, 2026

Study Completion Date

October 31, 2026

Conditions
NK-T-Cell Lymphoma, Extranodal
Interventions
DRUG

4 cycles of ESA regimen with sandwiched radiotherapy

Pegaspargase, 2500U/m2, i.m. d1; etoposide, 200mg, p.o., d2-d4; Dexamethasone, 40mg, p.o. d2-d4;

DRUG

2 cycles of ESA regimen sequential radiotherapy and 2 cycles of PD-1 monoclonal antibody combined with pegaspargase

Pegaspargase, 2500U/m2, IM, d1; PD-1 monoclonal antibody, 200mg, i.v. d2;

DRUG

2 cycles of ESA regimen, 2 cycles of PD-1 monoclonal antibody and concurrent radiotherapy, 2 cycles of PD-1 monoclonal antibody combined with pegaspargase

PD-1 monoclonal antibody, 200mg, i.v. d1

Trial Locations (1)

200020

RECRUITING

Ruijin Hospital, Shanghai

All Listed Sponsors
lead

Ruijin Hospital

OTHER