Thoracic Epidural Anesthesia Reduces Mortality and Rehospitalization for Patients With Heart Failure With Reduced Ejection Fraction

NACompletedINTERVENTIONAL
Enrollment

1,840

Participants

Timeline

Start Date

July 1, 2013

Primary Completion Date

August 31, 2019

Study Completion Date

August 31, 2023

Conditions
Heart Failure With Reduced Ejection FractionThoracic Epidural Anesthesia
Interventions
COMBINATION_PRODUCT

TEA plus GDMT

Thoracic epidural anesthesia (TEA), the infusion of anesthetic agents (eg, lidocaine or ropivacaine) into the epidural space, is used to achieve sympathetic block at the T1 to T4 levels in thoracic and abdominal surgical procedures. Since 1995, Professor Liu Fengqi has pioneered the use of TEA to treat end-stage HFrEF and achieved surprising results. TEA could reduce the enlarged heart cavity, halt and reverse cardiac remodeling, and improve cardiac systolic and diastolic function. Currently, thousands of HFrEF patients have received TEA procedure. All the patients received maximally tolerated guideline-directed medical therapy (GDMT).

DRUG

GDMT

All the patients received maximally tolerated guideline-directed medical therapy (GDMT) alone.

All Listed Sponsors
lead

First Affiliated Hospital of Harbin Medical University

OTHER

NCT06068166 - Thoracic Epidural Anesthesia Reduces Mortality and Rehospitalization for Patients With Heart Failure With Reduced Ejection Fraction | Biotech Hunter | Biotech Hunter