AMG510 (sotorasib) Plus Lenvatinib As Second-line Treatment in Patients with KRASG12C Mutant, Metastatic NSCLC

PHASE2WithdrawnINTERVENTIONAL
0
Timeline

Start Date

March 31, 2025

Primary Completion Date

September 30, 2026

Study Completion Date

December 30, 2026

Conditions
Metastatic Non Small Cell Lung CancerKRAS G12C
Interventions
DRUG

Sotorasib

Sotorasib is administered at a dose of 960 mg (8x 120 mg) orally, once daily until progression or unacceptable toxicity.

DRUG

Lenvatinib

Lenvatinib is administered at a dose of 20 mg orally (2x 10 mg), once daily until progression or unacceptable toxicity.

Trial Locations (15)

Unknown

Medical University of Innsbruck / UK für Innere Medizin V, Innsbruck

University Hospital of Munich (LMU), Department of Medicine V (Pneumology/Thoracic Oncology), Munich

Alicante University Dr Balmis Hospital ISABIAL, Alicante

Ico Badalona - Hospital Germans Trias I Pujol, Badalona

Hospital Universitario Lucus Augusti, Lugo

Hospital Universitario de Salamanca, Salamanca

Hospital Universitario Nuestra Señora de Candelaria, Santa Cruz de Tenerife

Hospital Universitario Virgen Del Rocio, Seville

Hospital Universitario de Toledo, Toledo

Hospital Universitario Y Politécnico La Fe, Valencia

Istituto Oncologico della Svizzera Italiana, Bellinzona

Kantonsspital Graubünden, Chur

HFR Fribourg, Fribourg

HUG, Geneva

Kantonsspital Winterthur, Winterthur

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Amgen

INDUSTRY

collaborator

Eisai Inc.

INDUSTRY

lead

ETOP IBCSG Partners Foundation

NETWORK