AMT-260 Gene Therapy Study in Adults With Unilateral Refractory Mesial Temporal Lobe Epilepsy

PHASE1/PHASE2RecruitingINTERVENTIONAL
Enrollment

12

Participants

Timeline

Start Date

June 12, 2024

Primary Completion Date

November 30, 2026

Study Completion Date

December 31, 2031

Conditions
Mesial Temporal Lobe Epilepsy
Interventions
GENETIC

AAV9-hSyn1-miGRIK2

AMT-260 is an AAV9 gene therapy product that locally delivers miRNA silencing technology to target the GRIK2 gene and suppress aberrantly expressed GluK2 containing kainate receptors. Intervention will be a one-time intracerebral administration of AMT-260.

Trial Locations (18)

15212

NOT_YET_RECRUITING

Allegheny Health Network, Pittsburgh

19104

RECRUITING

Hospital of the University of Pennsylvania, Philadelphia

20817

RECRUITING

Midatlantic Epilepsy and Sleep Center, Bethesda

21287

RECRUITING

Johns Hopkins School of Medicine, Baltimore

32224

RECRUITING

Mayo Clinic Florida, Jacksonville

43210

RECRUITING

Ohio State University, Columbus

44195

RECRUITING

Cleveland Clinic, Cleveland

49503

RECRUITING

Corewell Health, Grand Rapids

53226

NOT_YET_RECRUITING

Medical College of Wisconsin, Milwaukee

66160

NOT_YET_RECRUITING

Kansas University Medical Center, Kansas City

78735

RECRUITING

Baylor Scott & White Medical Center, Austin

85054

RECRUITING

Mayo Clinic Arizona, Phoenix

94304

RECRUITING

Stanford University, Palo Alto

35294-0021

RECRUITING

University of Alabama at Birmingham, Birmingham

02114

RECRUITING

Massachusetts General Hospital, Boston

03756

RECRUITING

Dartmouth Hitchcock Medical Center, Lebanon

07601

RECRUITING

Northeast Regional Epilepsy Group, Hackensack

08901

RECRUITING

Robert Wood Johnson Hospital, New Brunswick

All Listed Sponsors
lead

UniQure Biopharma B.V.

INDUSTRY