34
Participants
Start Date
August 7, 2024
Primary Completion Date
December 31, 2029
Study Completion Date
December 31, 2030
Bevacizumab
Participants will receive 10mg/kg of Bevacizumab intravenously (IV) on Day 1 and Day 15 of each repeated cycle of treatment.
PD-L1 t-haNK
Participants will receive PD-L1 t-haNK (\~2 × 109 cells/infusion) intravenously (IV) on Day 1 and Day 15 of each repeated cycle of treatment.
N-803
Participants will receive 1mg subcutaneously (SC) on Day 1 and Day 15 of each repeated cycle of treatment.
Tumor Treating Fields (TTFields, 200 kHz)
"TTFields (OPTUNE Gio®), for the treatment of newly diagnosed and/or recurrent GBM, is a portable battery or power supply operated device which produces alternating electrical fields, called tumor treatment fields (TTFields) within the human body/brain. TTFields are applied to the patient by electrically-insulated surface transducer arrays. TTFields disrupt the rapid cell division exhibited by cancer cells. TTFields is comprised of two main components: (1) an Electric Field Generator and (2) INE Insulated Transducer Arrays (the transducer arrays). Patients carry the device in an over-the-shoulder bag or backpack and receive continuous treatment without changing their daily routine."
Chan Soon-Shiong Institute for Medicine (CSSIFM), El Segundo
Hoag Memorial Hospital Presbyterian, Newport Beach
Providence Medical Foundation, Fullerton
Lead Sponsor
ImmunityBio, Inc.
INDUSTRY