A Clinical Study of Chemoradiotherapy Sequential Fluzoparib in Pan-solid Tumors

PHASE2Not yet recruitingINTERVENTIONAL
Enrollment

120

Participants

Timeline

Start Date

November 1, 2023

Primary Completion Date

November 30, 2024

Study Completion Date

May 31, 2026

Conditions
PARP Inhibitor for Esophageal Squamous Cell Carcinoma
Interventions
DRUG

Fluzoparib monotherapy or Fluzoparib with Camrelizumab(Only non-small cell lung cancer arm) ,or Fluzoparib combined with capecitabine (only rectal cancer arm))

Arm A: untreated surgically resectable rectal cancer. Patients accept preoperative long-range synchronous chemoradiotherapy → fluzoparib combined with capecitabine (Q3W, 4 treatment cycles) → surgery → observation and follow-up Arm B, C and D: include untreated locally advanced unresectable non-small cell lung cancer, esophageal squamous cell carcinoma and cervical carcinoma. Patients accept radical synchronous chemoradiotherapy following → fluzoparib combined with camrelizumab or fluzoparib monotherapy maintenance treatment for 17 cycles

All Listed Sponsors
lead

Chongqing University Cancer Hospital

OTHER