144
Participants
Start Date
October 8, 2023
Primary Completion Date
April 27, 2025
Study Completion Date
April 27, 2025
YN001
In single ascending dose (SAD) part of study in health subjects, YN001 will be administrated one time with dosage from 10 mg to 120 mg (planned). In multiple ascending doses (MAD) part of study in health subjects, YN001 will be given twice a week from 5 mg to 40 mg up to 15 days. In MAD part of study in patients with coronary atherosclerosis, YN001 will be injected weekly or twice a week from 5mg to 40mg up to 85 days.
Placebo for YN001
The injection solution to mimic the YN001
rosuvastatin calcium tablets
In MAD part of study in patients with coronary atherosclerosis, Rosuvastatin calcium tablets will be taken orally by 10 mg daily up to 85 days
Beijing Anzhen Hospital, Capital Medical University, Beijing
Peking University first hospital, Beijing
First Hospital of Jilin University, Changchun
Renmin Hospital of Wuhan University, Wuhan
Zhongnan Hospital of Wuhan University, Wuhan
Renji Hospital Shanghai Jiaotong Unv. school of Medicine, Shanghai
Beijing Inno Medicine Co., Ltd.
INDUSTRY