A Single Center, Single Arm Clinical Study on the Treatment of Advanced Non-small Cell Lung Cancer With Positive EGFR Sensitive Mutations and Failed EGFR TKIs With the Combination of Enrotinib and Paclitaxel Monoclonal Antibody

PHASE3Not yet recruitingINTERVENTIONAL
Enrollment

52

Participants

Timeline

Start Date

September 30, 2023

Primary Completion Date

June 30, 2026

Study Completion Date

September 30, 2026

Conditions
Lung CancerTKI ResistanceEGFR Sensitive MutationAnlotinibPianzumab
Interventions
DRUG

Anlotinib

Every 3 weeks is a treatment cycle, starting from the first day of each treatment cycle with oral administration of 12mg of arotinib once a day, stopping for one week after taking it for two weeks until disease progression (PD), unacceptable toxic reactions, withdrawal of informed consent, end of study, loss of follow-up or death, whichever occurs first.

DRUG

Penpulimab

On the first day, Pianzumab (200mg intravenous infusion) was administered every 3 weeks until disease progression (PD), unacceptable toxic reactions, withdrawal of informed consent, end of study, loss of follow-up or death, whichever occurs first.

All Listed Sponsors
collaborator

Wu Jieping Medical Foundation

OTHER

lead

Degan Lu

OTHER

NCT06048315 - A Single Center, Single Arm Clinical Study on the Treatment of Advanced Non-small Cell Lung Cancer With Positive EGFR Sensitive Mutations and Failed EGFR TKIs With the Combination of Enrotinib and Paclitaxel Monoclonal Antibody | Biotech Hunter | Biotech Hunter