Can Immediate Post-injury Fluoxetine Improve the Recovery Trajectories of Victims in Bodily Trauma?

PHASE4RecruitingINTERVENTIONAL
Enrollment

200

Participants

Timeline

Start Date

March 1, 2024

Primary Completion Date

November 30, 2027

Study Completion Date

November 30, 2027

Conditions
Musculoskeletal Injury
Interventions
DRUG

Fluoxetine

Subjects will be randomized to take Fluoxetine (10mg by mouth per day for first 14 days then 20 mg by mouth for 9 months). The randomized drug will be prescribed by the study team on the day of randomization so that the patient may be monitored for side effects during the remainder of their hospitalization. The patient will be prescribed the randomized medication on the day of discharge and a 90 day supply will be provided by the inpatient research pharmacy at the 2 week, 3 month, and 6 month follow-up visits

DRUG

Placebo

When a patient is enrolled, the inpatient research pharmacy will dispense the appropriately randomized medication in a visually similar, over-encapsulated form as Fluoxetine

Trial Locations (1)

32608

RECRUITING

University of Florida, Gainesville

All Listed Sponsors
lead

University of Florida

OTHER