Safety and Pharmacokinetic Study of Oral MK-8527 QM in Participants at Low-Risk for HIV-1 Infection (MK-8527-007)

PHASE2CompletedINTERVENTIONAL
Enrollment

352

Participants

Timeline

Start Date

November 8, 2023

Primary Completion Date

December 12, 2024

Study Completion Date

February 12, 2025

Conditions
HIVHIV Pre-exposure Prophylaxis
Interventions
DRUG

MK-8527

MK-8527 capsule

DRUG

Placebo to MK-8527

Placebo capsule matched to MK-8527

Trial Locations (18)

2000

Wits RHI-Wits RHI Ward 21 Clinical Research site ( Site 0027), Johannesburg

2092

Helen Joseph Hospital ( Site 0024), Johannesburg

3370

Qhakaza Mbokodo Research Clinic ( Site 0026), Ladysmith

7925

Desmond Tutu Health Foundation ( Site 0021), Cape Town

9301

Josha Research ( Site 0023), Bloemfontein

15213

University of Pittsburgh Medical Center-Division of Infectious Diseases ( Site 0041), Pittsburgh

20854

Velocity Clinical Research Rockville ( Site 0048), Rockville

33009

Velocity Clinical Research, Hallandale Beach ( Site 0052), Hallandale

34142

Community Medical Care Center ( Site 0056), Immokalee

75208

Prism Health North Texas, Oak Cliff Health Center ( Site 0045), Dallas

87102

Albuquerque Clinical Trials, Inc. ( Site 0044), Albuquerque

91606

Velocity Clinical Research, North Hollywood ( Site 0054), North Hollywood

94102

Bridge HIV- San Francisco Department of Public Health ( Site 0042), San Francisco

98104

Fred Hutchinson Cancer Center - The Seattle HIV Vaccine Trials Unit ( Site 0057), Seattle

3109601

Rambam Health Care Campus ( Site 0003), Haifa

5265601

Sheba Medical Center ( Site 0001), Ramat Gan

9112001

Hadassah Medical Center ( Site 0002), Jerusalem

02215

Fenway Health ( Site 0043), Boston

All Listed Sponsors
lead

Merck Sharp & Dohme LLC

INDUSTRY

NCT06045507 - Safety and Pharmacokinetic Study of Oral MK-8527 QM in Participants at Low-Risk for HIV-1 Infection (MK-8527-007) | Biotech Hunter | Biotech Hunter