77
Participants
Start Date
September 30, 2023
Primary Completion Date
September 30, 2027
Study Completion Date
September 30, 2027
Ultrasound
The General Electric LOGIQ E10 ultrasound pulsed doppler imaging system and C1-6-D XDclear abdominal curvilinear probe will be used to administer ultrasound.
OGTT with unlabeled glucose and liver NMR
Subjects will undergo an OGTT with unlabeled glucose to measure liver glycogen concentration by NMR spectroscopy.
OGTT with carbon-13 labeled glucose and liver NMR
Subjects will undergo an OGTT with carbon-13 labeled glucose to measure liver glycogen synthesis rate by NMR spectroscopy.
CGM glucose reading
A continuous glucose monitor (CGM) will be collecting glucose level changes over a 10-14day time period after the ultrasound.
HEC - Hyperinsulinemic-Euglycemic-Clamp
A constant i.v. insulin and variable glucose infusion will be used to determine insulin sensitivity of study participants.
RECRUITING
Yale School of Medicine, New Haven
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NIH
Yale University
OTHER