Early Adalimumab Induction for Immune Checkpoint Inhibitor Associated Inflammatory Arthritis

PHASE2RecruitingINTERVENTIONAL
Enrollment

30

Participants

Timeline

Start Date

April 15, 2024

Primary Completion Date

November 30, 2025

Study Completion Date

November 30, 2025

Conditions
Inflammatory ArthritisImmune-related Adverse Event
Interventions
DRUG

Adalimumab

Participants will be randomized 1:1 (non-blinded) to receive either adalimumab (40 mg subcutaneous every 2 weeks for 12 weeks) and prednisone vs prednisone alone. Addition of methotrexate (MTX) and/or hydroxychloroquine (HCQ) is permitted, as needed, at the discretion of the treating rheumatologist. No additional conventional synthetic, targeted synthetic or biologic DMARDs are permitted during the trial.

DRUG

Prednisone

Prednisone as per standard of care.

Trial Locations (1)

N6A 4V2

RECRUITING

St. Joseph's Health Care, London

All Listed Sponsors
collaborator

Canadian Research Group in Immuno-Oncology

UNKNOWN

collaborator

Western University

OTHER

lead

Tom Appleton

OTHER