Nalbuphine in ARDS Patients After Surgery

PHASE4RecruitingINTERVENTIONAL
Enrollment

60

Participants

Timeline

Start Date

September 1, 2023

Primary Completion Date

April 28, 2026

Study Completion Date

November 30, 2026

Conditions
Acute Respiratory Distress Syndrome
Interventions
DRUG

Nalbuphine

Nalbuphine was injected intravenously. The target CPOT score was \<2, and the target RASS score was -2 \~ 1. 40 mg of nalbuphine was diluted into 50 mL solution, the load was 0.1mg/kg, the maintenance dose was 0.04-0.08mg/kg/h, the CPOT score was \<2, and the maximum daily dose was 160mg.

DRUG

Sufentanil

Sufentanil was injected intravenously, and the target CPOT score was \<2, and the target RASS score was -2 \~ 1. 0.1mg of sufentanil was diluted into 50 mL solution, the loading dose was 0.2-0.5μg/kg, the maintenance dose was 0.2-0.3μg/kg/h, and the CPOT score was \<2 points

Trial Locations (1)

250014

RECRUITING

Department of Intensive Care Medicine, Jinan

All Listed Sponsors
lead

Hairong Chen

OTHER