A Trial to Evaluate an HIV Envelope Trimer, N332-GT5 gp140, Adjuvanted With SMNP in Adult Participants Without HIV

PHASE1Active, not recruitingINTERVENTIONAL
Enrollment

57

Participants

Timeline

Start Date

November 27, 2023

Primary Completion Date

October 30, 2025

Study Completion Date

July 21, 2026

Conditions
HIV
Interventions
BIOLOGICAL

N332-GT5 gp140 (IM, Bolus)

IM in the deltoid

BIOLOGICAL

N332-GT5 gp140 (IM, Fractioned)

IM in the deltoid, Fractionated escalating dose for prime

BIOLOGICAL

N332-GT5 gp140 (SC, Bolus)

SC in the upper arm

BIOLOGICAL

N332-GT5 gp140 (SC, Fractioned)

SC in the upper arm, Fractionated escalating dose for prime

BIOLOGICAL

SMNP (IM, Bolus)

IM in the deltoid

BIOLOGICAL

SMNP (IM, Fractioned)

IM in the deltoid, Fractionated escalating dose for prime

BIOLOGICAL

SMNP (SC, Bolus)

SC in the upper arm

BIOLOGICAL

SMNP (SC, Fractioned)

SC in the upper arm, Fractionated escalating dose for prime

Trial Locations (8)

10065

New York Blood Center, New York

14642

University of Rochester Medical Center, Rochester

19104

Penn Prevention CRS [Site ID: 30310], Philadelphia

30030

Atlanta - Hope Clinic, Decatur

94102

Bridge HIV CRS, San Francisco

100032

Columbia University Medical Center, New York

02115

Brigham & Women's Hospital, Boston

37232-2582

Vanderbilt Institute for Infection, Immunology and Inflammation, Nashville

All Listed Sponsors
collaborator

National Institutes of Health (NIH)

NIH

collaborator

Department of Health and Human Services

FED

lead

National Institute of Allergy and Infectious Diseases (NIAID)

NIH

NCT06033209 - A Trial to Evaluate an HIV Envelope Trimer, N332-GT5 gp140, Adjuvanted With SMNP in Adult Participants Without HIV | Biotech Hunter | Biotech Hunter