Fluad vs. Fluzone High-Dose Vaccine Effectiveness Among Adults ≥65 Years

RecruitingOBSERVATIONAL
Enrollment

960,000

Participants

Timeline

Start Date

August 17, 2023

Primary Completion Date

May 31, 2025

Study Completion Date

May 31, 2026

Conditions
InfluenzaCommunity-acquired PneumoniaCardiovascular Events
Interventions
BIOLOGICAL

Adjuvanted Quadrivalent Inactivated Influenza Vaccine (aIIV4)

Fluad Quadrivalent vaccine is an inactivated influenza vaccine formulated to contain 60 mcg of hemagglutinin (HA) total, with 15 mcg from each of the four recommended influenza strains and the MF59 adjuvant in single-dose prefilled 0.5 mL syringes. Kaiser Permanente Northern California members ≥65 years may receive Fluad as part of routine clinical care during the influenza season.

BIOLOGICAL

High-Dose Quadrivalent Inactivated Influenza Vaccine (HD-IIV4)

Fluzone High-Dose Quadrivalent vaccine is an inactivated split virion influenza vaccine formulated to contain 240 mcg of HA total, with 60 mcg from each of the four recommended influenza strains in single-dose prefilled 0.7 mL syringes. Kaiser Permanente Northern California members ≥65 years may receive Fluzone High-Dose as part of routine clinical care during the influenza season.

Trial Locations (1)

94612

RECRUITING

Kaiser Permanente Northern California (entire region), Oakland

All Listed Sponsors
collaborator

Seqirus

INDUSTRY

lead

Kaiser Permanente

OTHER