Zanubrutinib and Tafasitamab in Mantle Cell Lymphoma

PHASE1/PHASE2RecruitingINTERVENTIONAL
Enrollment

27

Participants

Timeline

Start Date

May 3, 2024

Primary Completion Date

May 1, 2028

Study Completion Date

May 1, 2032

Conditions
Mantle Cell Lymphoma
Interventions
DRUG

Zanubrutinib

"Participants will be administered Zanubrutinib orally (PO) via capsules daily during each 28-day cycle at the following dose levels:~* Phase 1 Dose Level 1: 320 mg~* Phase 1 Dose Level -1: 240 mg~* Phase 2: Recommended dose determined in Phase 1."

DRUG

Tafasitamab

"Participants will be administered a 12 mg/kg dose of Tafasitamab intravenously (IV) during each 28-day cycle as follows:~* Early Induction - Cycle 1: Days 1, 4, 8, 15, and 22~* Early Induction - Cycles 2 and 3: Days 1, 8, 15 and 22~* Late Induction - Cycles 4 through 12: Days 1 and 15"

Trial Locations (1)

33136

RECRUITING

University of Miami, Miami

Sponsors
All Listed Sponsors
collaborator

BeiGene

INDUSTRY

collaborator

Incyte Corporation

INDUSTRY

collaborator

MorphoSys AG

INDUSTRY

lead

Alvaro Alencar, MD

OTHER

NCT06029309 - Zanubrutinib and Tafasitamab in Mantle Cell Lymphoma | Biotech Hunter | Biotech Hunter