AOrtic Surgery: Systemic Inflammatory Response Versus Sepsis

RecruitingOBSERVATIONAL
Enrollment

60

Participants

Timeline

Start Date

April 1, 2022

Primary Completion Date

June 30, 2024

Study Completion Date

June 30, 2024

Conditions
Systemic Inflammatory Response SyndromeInfectionsThoracic Aortic AneurysmAortic DiseasesImmunological Abnormality
Interventions
DIAGNOSTIC_TEST

Blood sample test

"The following groups of biomarkers will be examined:~* standard panel of inflammation markers: CRP, PCT, IL-6, Leukocyte count, differential blood count~* microbiology cultures according to the clinical status~* serum biomarkers: sCD64, sTREM-1, calprotectin, pentraxin 3~* flow cytometry: HLA-DR, CD14, CD16, CD40, CD45, CD64, CD163 expression on granulocytes and monocytes~* cell function assay: IL-18 and IFN-γ~* hematology: ICIS, Neutrophil-to-lymphocyte ratio - examined together with conventional hematological parameters.~The schedule of blood sample taking will be as follows:~A. the study group: preoperatively (T-1), 1st postoperative day (T1), 3rd postoperative day (T2), 7th postoperative day (T3), 10th postoperative day (T4)~B. the control group: at admission or the next day (T1), 3rd day of hospital stay (T2), 7th day of hospital stay (T3), 10th day of hospital stay (T4)"

PROCEDURE

Thoracic Aortic Surgery

Scheduled surgical intervention, i.e. replacement of pre-specified part of thoracic aorta by a vascular prosthesis.

Trial Locations (1)

500 02

RECRUITING

University Hospital Hradec Králové, Hradec Králové

All Listed Sponsors
collaborator

American Association for Thoracic Surgery

UNKNOWN

lead

University Hospital Hradec Kralove

OTHER