A Three-arm Randomized Phase II Study of Dostarlimab Alone or With Bevacizumab Versus Nonplatinum Chemotherapy in Recurrent Gynecological Clear Cell Carcinoma: DOVE (APGOT-OV7/ ENGOT-ov80 Study)

PHASE2RecruitingINTERVENTIONAL
Enrollment

198

Participants

Timeline

Start Date

January 22, 2024

Primary Completion Date

August 31, 2027

Study Completion Date

December 31, 2029

Conditions
Ovarian NeoplasmsEndometrial NeoplasmsUterine Cervical NeoplasmsVulvar CancerVagina NeoplasmClear Cell Carcinoma
Interventions
DRUG

Dostarlimab

Intravenous (IV) infusion

DRUG

Bevacizumab

Intravenous (IV) infusion

DRUG

Doxorubicin

Intravenous (IV) infusion

DRUG

Gemcitabine

Intravenous (IV) infusion

DRUG

Paclitaxel

Intravenous (IV) infusion

DRUG

Pegylated liposomal doxorubicin

Intravenous (IV) infusion

Trial Locations (18)

830-0011

RECRUITING

Kurume University Hospital, Kurume

960-1295

RECRUITING

Fukushima Medical University Hospital, Fukushima

514-8507

RECRUITING

Mie University Hospital, Tsu

980-8574

RECRUITING

Tohoku University Hospital, Sendai

951-8566

RECRUITING

Niigata Cancer Center Hospital, Niigata

1397-1

RECRUITING

Saitama Medical University International Medical Center, Hidaka

770-8501

RECRUITING

Tokushima University Hospital, Tokushima

105-0003

RECRUITING

The Jikei University Hospital, Tokyo

135-8550

RECRUITING

The Cancer Institute Hospital Of JFCR, Tokyo

305-8576

RECRUITING

University of Tsukuba Hospital, Tsukuba

Unknown

NOT_YET_RECRUITING

National University Hospital, Singapore

RECRUITING

National Cancer Center, Goyang-si

RECRUITING

Bundang Seoul National University Hospital, Seongnam-si

RECRUITING

Asan Medical Center, Seoul

RECRUITING

Korea University Guro Hospital, Seoul

RECRUITING

Samsung Medical Center, Seoul

RECRUITING

Seoul National University, Seoul

03722

RECRUITING

Severance Hospital, Yonsei Health System, Seoul

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

GlaxoSmithKline

INDUSTRY

lead

Yonsei University

OTHER