Extended-release Buprenorphine Compared to Sublingual Buprenorphine in Rural Settings (RXR)

PHASE3RecruitingINTERVENTIONAL
Enrollment

144

Participants

Timeline

Start Date

October 14, 2024

Primary Completion Date

October 31, 2025

Study Completion Date

February 28, 2026

Conditions
Opioid-Related DisordersSubstance-Related DisordersNarcotic-Related Disorders
Interventions
DRUG

Injectable extended-release buprenorphine

Participants randomized to the XR-BUP condition will receive XR-BUP study medication for approximately 14 weeks following randomization, including an initial \~2-week period of induction/stabilization.

DRUG

Sublingual buprenorphine-naloxone

Participants randomized to the SL-BUP condition will receive SL-BUP study medication for approximately 14 weeks following randomization, including an initial \~2-week period of induction/stabilization.

Trial Locations (7)

26155

NOT_YET_RECRUITING

New Beginnings Recovery Clinic & Behavioral Health Center, New Martinsville

60936

RECRUITING

Gibson Area Hospital and Health Services - Gibson Recovery Optimizing Wellness, Gibson City

71730

RECRUITING

AppleGate Recovery El Dorado, El Dorado

95542

RECRUITING

Southern Humboldt Community Healthcare District - Jerold Phelps Community Hospital, Garberville

97056

RECRUITING

Oregon Health & Science University Primary Care Clinic, Scappoose, Scappoose

99114

RECRUITING

Providence Northeast Washington Medical Group, Colville

04915

RECRUITING

Penobscot Community Health Care Inc. - Seaport Community Health Center, Belfast

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

National Institute on Drug Abuse (NIDA)

NIH

collaborator

National Institutes of Health (NIH)

NIH

collaborator

The Emmes Company, LLC

INDUSTRY

collaborator

University of California, Los Angeles

OTHER

collaborator

RAND

OTHER

collaborator

Cornell University

OTHER

collaborator

Oregon Health and Science University

OTHER

collaborator

University of Illinois at Chicago

OTHER

collaborator

University of Washington

OTHER

collaborator

West Virginia University

OTHER

lead

Yih-Ing Hser

OTHER

NCT06023459 - Extended-release Buprenorphine Compared to Sublingual Buprenorphine in Rural Settings (RXR) | Biotech Hunter | Biotech Hunter