Study of MCLA-129 Combined With Befotertinib in the Treatment of Advanced Non-small Cell Lung Cancer With EGFR Sensitive Mutation

PHASE1Not yet recruitingINTERVENTIONAL
Enrollment

172

Participants

Timeline

Start Date

September 1, 2023

Primary Completion Date

November 4, 2028

Study Completion Date

July 4, 2029

Conditions
Non-Small Cell Lung Cancer、EGFR Sensitive Mutation
Interventions
DRUG

MCLA-129: 1500mg or 2000mg IV Q2W

Every 28 days is a cycle until disease progression, death, initiation of new anti-tumor treatment, loss of follow-up, or voluntary withdrawal occurs

DRUG

Befotertinib: 75 mg or 100 mg Po QD

"The initial dose of Befotertinib is 75 mg orally once daily (QD) for one cycle, and then increased to 100 mg orally QD in the absence of CTCAE grade ≥ 2 headache or thrombocytopenia during the first cycle, otherwise maintained to 75 mg orally QD.~Every 28 days is a cycle until disease progression, death, initiation of new anti-tumor treatment, loss of follow-up, or voluntary withdrawal occurs."

Trial Locations (3)

Unknown

The first affiliated hospital of bengbu medical college, Bengbu

Hunan cancer hospital, Changsha

Shanghai chest hospital, Shanghai

All Listed Sponsors
lead

Betta Pharmaceuticals Co., Ltd.

INDUSTRY