A Study to Evaluate LBL-007 in Combination With Tislelizumab Plus Chemotherapy in Participants With Unresectable Locally Advanced or Metastatic Esophageal Squamous Cell Carcinoma

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

118

Participants

Timeline

Start Date

November 8, 2023

Primary Completion Date

September 11, 2024

Study Completion Date

May 23, 2026

Conditions
Esophageal CancerEsophageal Squamous Cell CarcinomaEsophageal Squamous Cell Carcinoma by AJCC V8 Stage
Interventions
DRUG

LBL-007

LBL-007 will be administered at a standard dose intravenously.

DRUG

Tislelizumab

Tislelizumab will be administered at a standard dose intravenously.

DRUG

Chemotherapy Doublet

"Doublet 1: cisplatin + 5-fluorouracil Doublet 2: cisplatin + paclitaxel~Choice of chemotherapy doublet will be determined by the investigator and will be administered at standard doses intravenously."

Trial Locations (38)

807

Kaohsiung Medical University Chung Ho Memorial Hospital, Kaohsiung City

10048

National Taiwan University Hospital, Taipei

10400

Ramathibodi Hospital Mahidol University, Bangkok

Phramongkutklao Hospital, Ratchathewi

10408

National Cancer Center, Goyang-si

10700

Siriraj Hospital, Bangkok

11217

Taipei Veterans General Hospital, Taipei

26120

Hrh Princess Maha Chakri Sirindhorn Medical Center (Srinakharinwirot University), Ongkharak

40447

China Medical University Hospital, Taichung

50006

Changhua Christian Hospital, Changhua

58128

Chonnam National University Hwasun Hospital, HwasunGun

100730

Peking Union Medical College Hospital, Beijing

150000

Harbin Medical University Cancer Hospital, Harbin

210008

Nanjing Drum Tower Hospital,the Affiliated Hospital of Nanjing University Medical School, Nanjing

213000

The First Peoples Hospital of Changzhou, Changzhou

221000

The Affiliated Hospital of Xuzhou Medical University, Xuzhou

226000

Nantong Tumor Hospital Branch North, Nantong

230000

Anhui Provincial Hospital, Hefei

The First Affiliated Hospital of Anhui Medical University, Hefei

250117

Shandong Cancer Hospital, Jinan

271099

The Second Affiliated Hospital of Shandong First Medical University, Taian

300060

Tianjin Medical University Cancer Institute and Hospital, Tianjin

350001

Fujian Medical University Union Hospital, Fuzhou

350014

Fujian Cancer Hospital, Fuzhou

410013

Hunan Cancer Hospital, Changsha

450000

Henan Cancer Hospital, Zhengzhou

450052

The First Affiliated Hospital of Zhengzhou University, Zhengzhou

453100

The First Affiliated Hospital of Xinxiang Medical University, Xinxiang

455001

Anyang Cancer Hospital, Anyang

473000

Nanyang Central Hospital, Nanyang

530021

The Tumor Hospital Affiliated to Guangxi Medical University, Nanning

610041

Sichuan Cancer Hospital and Institute, Chengdu

610071

Sichuan Academy of Medical Sciences and Sichuan Provincial Peoples Hospital, Chengdu

730030

Lanzhou University Second Hospital, Lanzhou

750004

General Hospital of Ningxia Medical University, Yinchuan

03080

Seoul National University Hospital, Seoul

03722

Severance Hospital Yonsei University Health System, Seoul

06591

The Catholic University of Korea, Seoul St Marys Hospital, Seoul

Sponsors

Lead Sponsor

All Listed Sponsors
lead

BeiGene

INDUSTRY