50
Participants
Start Date
February 22, 2024
Primary Completion Date
March 1, 2026
Study Completion Date
March 1, 2026
Near Apnoeic ventilation
Near Apnoeic ventilation (with a respiratory rate of 2 breaths per minute, plateau pressure of 30cmH20 and PEEP set according to the mean airway pressure being delivered during mechanical ventilation prior to randomisation) for a 72 hour period following randomisation
Crossover standardised ECMO weaning trials
"When all patients are eligible for a trial of ECMO weaning, they will have standardised ECMO weaning trials lasting up to 1 hour with 0 sweep gas flow. 1) One-stage weaning- sweep gas flow rate sequentially decreased to zero 2) Two-stage weaning- fraction of oxygen of sweep gas flow decreased to 0.21 sequentially. Then the sweep gas flow rate decreased to 0 sequentially"
RECRUITING
Guys & St. Thomas' NHS Foundation Trust, London
Guy's and St Thomas' NHS Foundation Trust
OTHER