IMV to Accelerate Recovery of Lung Function in Veno-venous Extracorporeal Membrane Oxygenation; Lung Rest Or Moderate Mechanical Ventilation in ECMO

NARecruitingINTERVENTIONAL
Enrollment

50

Participants

Timeline

Start Date

February 22, 2024

Primary Completion Date

March 1, 2026

Study Completion Date

March 1, 2026

Conditions
ARDS
Interventions
OTHER

Near Apnoeic ventilation

Near Apnoeic ventilation (with a respiratory rate of 2 breaths per minute, plateau pressure of 30cmH20 and PEEP set according to the mean airway pressure being delivered during mechanical ventilation prior to randomisation) for a 72 hour period following randomisation

OTHER

Crossover standardised ECMO weaning trials

"When all patients are eligible for a trial of ECMO weaning, they will have standardised ECMO weaning trials lasting up to 1 hour with 0 sweep gas flow. 1) One-stage weaning- sweep gas flow rate sequentially decreased to zero 2) Two-stage weaning- fraction of oxygen of sweep gas flow decreased to 0.21 sequentially. Then the sweep gas flow rate decreased to 0 sequentially"

Trial Locations (1)

SE1 7EH

RECRUITING

Guys & St. Thomas' NHS Foundation Trust, London

All Listed Sponsors
lead

Guy's and St Thomas' NHS Foundation Trust

OTHER

NCT06006676 - IMV to Accelerate Recovery of Lung Function in Veno-venous Extracorporeal Membrane Oxygenation; Lung Rest Or Moderate Mechanical Ventilation in ECMO | Biotech Hunter | Biotech Hunter