260
Participants
Start Date
September 5, 2023
Primary Completion Date
September 30, 2027
Study Completion Date
September 30, 2032
Mosunetuzumab + Lenalidomide
"* Mosunetuzumab will be administered SC (21 days first cycle, then 28 days next cycles)~ * C1 (21-days cycle): step-up dosing schedule 5 mg Day 1, 45 mg on Day 8 and 45 mg Day 15~ * C2 to C12: 45 mg D1 28-days cycles~* Lenalidomide PO 20 mg/day from Day 1 to Day 21 from cycles C2 to C6 (cycles of 28 days)"
- Rituximab + Lenalidomide (28-days cycles
"* Lenalidomide PO 20 mg/day, D1-21 from cycle 1 to cycle 6~* Rituximab\* 375 mg/m2 intravenously at Day 1 cycle 1, and then subcutaneous (1400 mg, flat dose) at D1 of cycles 2-12"
- Rituximab + Bendamustine (28-days cycles)
"* Bendamustine IV 70 or 90 mg/m² (according to the investigator's judgment) D1 and D2/28 days x 6 cycles 28 days cycles). For patients in complete response (CR) at 3 cycles, Bendamustine and Rituximab could be stopped after 4 cycles at investigator discretion~* Rituximab\* 375 mg/m2 intravenously at cycle 1 Day 1, and then subcutaneous (1400 mg, flat dose) at D1 of cycles 2 to 6\*\* (28-days cycles) and then at D1 of three additional 56-days cycles (C7 to C9). \*\*For patients in complete response (CR) at 3 cycles, if Bendamustine is stopped, then Rituximab should also be omitted for C5 and C6."
- Rituximab + CHOP (21-days cycles)
"* CHOP, IV standard dose from cycle 1 to 6~* Rituximab\* 375 mg/m2 intravenously at Day 1 cycle 1, and then subcutaneous (1400 mg, flat dose) at D1 of cycles 2 to 6 (21-days cycles), and then at D1 of three additional 56-days cycles (C7 to C9)"
NOT_YET_RECRUITING
INSTITUT JULES BORDET - Service Hématologie, Anderlecht
RECRUITING
INSTITUTO PORTUGUES DE ONCOLOGIA DE LISBOA FRANCISCO GENTIL - Departamento Hematologia, Lisbon
NOT_YET_RECRUITING
UNIVERSITE CATHOLIQUE DE LOUVAIN SAINT-LUC - Service Hématologie, Brussels
NOT_YET_RECRUITING
CHU UCL NAMUR - SITE GODINNE - Service Hématologie, Yvoir
NOT_YET_RECRUITING
UNIVERSITAIR ZIEKENHUIS GENT - Service Hématologie, Ghent
RECRUITING
CHU d'Amiens, Amiens
RECRUITING
CH d'Avignon - Hopital Henri Duffaut, Avignon
RECRUITING
CH de la Côte Basque - Hôpital de Bayonne, Bayonne
RECRUITING
CHRU Besançon - Hôpital Minjoz, Besançon
RECRUITING
Institut Bergonié, Bordeaux
RECRUITING
Chu Estaing, Clermont-Ferrand
RECRUITING
CHU Henri Mondor, Créteil
RECRUITING
CHU de Dijon, Dijon
RECRUITING
CHU de Grenoble - Hôpital Albert Michallon, La Tronche
RECRUITING
CHRU de LILLE - Claude Huriez, Lille
RECRUITING
Institut Paoli Calmette, Marseille
RECRUITING
CH Saint-Eloi, Montpellier
RECRUITING
CHU de Nancy - Brabois, Nancy
RECRUITING
Centre Catherine de Sienne, Nantes
RECRUITING
CHU de Nantes - Hôtel Dieu, Nantes
RECRUITING
Centre Antoine Lacassagne, Nice
RECRUITING
CHU de Nice, Nice
RECRUITING
CHR d'Orléans, Orléans
RECRUITING
APHP - Hôpital Saint Louis, Paris
RECRUITING
CHU Lyon Sud, Pierre-Bénite
RECRUITING
CHU de Rennes - Hôpital de Pontchaillou, Rennes
RECRUITING
Centre Henri Becquerel, Rouen
RECRUITING
Institut de Cancérologie de la Loire Lucien Neuwirth, Saint-Priest-en-Jarez
The Lymphoma Academic Research Organisation
OTHER