Efficacy and Safety of CsA+AVA in the Treatment of NSAA in the Elderly

PHASE2RecruitingINTERVENTIONAL
Enrollment

30

Participants

Timeline

Start Date

August 17, 2023

Primary Completion Date

August 31, 2024

Study Completion Date

August 31, 2025

Conditions
Aplastic Anemia
Interventions
DRUG

Ciclosporin

Cyclosporine was taken orally at 3-5mg/kg bid was administered to maintain the trough concentration at 100-200 μg/ml

DRUG

Avatrombopag

Avatrombopag was administrated at 40 mg/d and increased by 20 mg/d during the biweekly follow-up if platelet was not 20 × 109/L higher than baseline. AVA dose was gradually reduced if PLT ≥ 150 × 109/L. The maximum dose was 60 mg/d, while the minimum was 20 mg/week.

Trial Locations (1)

Unknown

RECRUITING

Peking union medical college hospital, Beijing

All Listed Sponsors
lead

Peking Union Medical College Hospital

OTHER