A Study to Evaluate the Safety, Pharmacokinetics, and Anti-Tumor Activity of VVD-133214 as Monotherapy and in Combination With Pembrolizumab in Participants With Advanced Solid Tumors

PHASE1RecruitingINTERVENTIONAL
Enrollment

295

Participants

Timeline

Start Date

January 25, 2024

Primary Completion Date

May 31, 2027

Study Completion Date

May 31, 2027

Conditions
Advanced Solid Tumors
Interventions
DRUG

VVD-133214

VVD-133214 will be administered orally and once daily (QD) in 3-week cycles.

DRUG

Pembrolizumab

Pembrolizumab will be administered by intravenous (IV) infusion at a fixed dose of 200 mg on Day 1 of each 21-day cycle.

Trial Locations (25)

2100

ACTIVE_NOT_RECRUITING

Rigshospitalet, København Ø

3000

ACTIVE_NOT_RECRUITING

UZ Leuven Gasthuisberg, Leuven

3181

ACTIVE_NOT_RECRUITING

Alfred Hospital, Melbourne

27705

COMPLETED

Duke University, Durham

28027

ACTIVE_NOT_RECRUITING

Clinica Universidad de Navarra Madrid, Madrid

28050

ACTIVE_NOT_RECRUITING

START Madrid. Centro Integral Oncologico Clara Campal, Madrid

31008

COMPLETED

Clinica Universitaria de Navarra, Pamplona

37203

ACTIVE_NOT_RECRUITING

SCRI Oncology Partners, Nashville

40202

ACTIVE_NOT_RECRUITING

Norton Cancer Institute - MDC, Louisville

46010

ACTIVE_NOT_RECRUITING

Hospital Clinico Universitario de Valencia, Valencia

69008

WITHDRAWN

CLCC Leon Berard Lyon, Lyon

73170

ACTIVE_NOT_RECRUITING

Oklahoma University Health Sciences Center, Oklahoma City

77030

ACTIVE_NOT_RECRUITING

MD Anderson Cancer Center, Houston

91010

ACTIVE_NOT_RECRUITING

City of Hope Cancer Center, Duarte

94805

ACTIVE_NOT_RECRUITING

Gustave Roussy, Villejuif

91355-9512

RECRUITING

City of Hope - Santa Clarita, Valencia

V5Z 4E6

WITHDRAWN

BCCA-Vancouver Cancer Centre, Vancouver

M5G 2M9

ACTIVE_NOT_RECRUITING

Princess Margaret Cancer Center, Toronto

463-707

RECRUITING

Seoul National University Bundang Hospital, Seongnam-si

03080

RECRUITING

Seoul National University Hospital, Seoul

05505

RECRUITING

Asan Medical Center, Seoul

08035

ACTIVE_NOT_RECRUITING

Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Barcelona

W1G 6AD

ACTIVE_NOT_RECRUITING

Sarah Cannon Research Institute, London

M20 4BX

ACTIVE_NOT_RECRUITING

The Christie, Manchester

SM2 5PT

COMPLETED

Royal Marsden Hospital (Sutton), Sutton

All Listed Sponsors
lead

Vividion Therapeutics, Inc.

INDUSTRY