A Study of Neoadjuvant TCHpy(Pyrotinib ,Trastuzumab,Carboplatin and Paclitaxel)for ER+/HER2+ Breast Cancer

PHASE2RecruitingINTERVENTIONAL
Enrollment

62

Participants

Timeline

Start Date

May 11, 2023

Primary Completion Date

May 11, 2025

Study Completion Date

May 11, 2028

Conditions
Breast CancerNeoadjuvant
Interventions
DRUG

pyrotinib,Trastuzumab,carboplatin,Albumin paclitaxel

"Pyrotinib tablets: 320mg qd, oral administration after breakfast, 21 days for 1 cycle, continuous administration of 6 cycles.~Trastuzumab: The first cycle was 8mg/kg, the second to sixth cycle was 6mg/kg, 21 days was 1 cycle, continuous administration of 6 cycles.~Albuminpaclitaxel: On the first day of cycle 1, 260mg/m2 was given intravenously, 21 days for 1 cycle, and 6 consecutive cycles were given.~Carboplatin: Endogenous creatinine clearance was calculated using the Cockcroft formula, with AUC 5 for the 1st to 6th cycle and 1 cycle for the 21st day and 6 consecutive cycles of administration"

Trial Locations (2)

430000

RECRUITING

WuhanHU, Wuhan

Unknown

RECRUITING

Union Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan

All Listed Sponsors
lead

Union Hospital, Tongji Medical College, Huazhong University of Science and Technology

OTHER