Study to Evaluate Safety and Antitumor Activity of Lete-Cel (GSK3377794) in HLA-A2+ Participants With NY-ESO-1 Positive Previously Untreated Advanced (Metastatic or Unresectable) Synovial Sarcoma and Myxoid/Round Cell Liposarcoma

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

7

Participants

Timeline

Start Date

December 31, 2019

Primary Completion Date

October 12, 2022

Study Completion Date

July 1, 2025

Conditions
Neoplasms
Interventions
DRUG

Letetresgene autoleucel

Letetresgene autoleucel will be administered.

DRUG

Cyclophosphamide

Cyclophosphamide will be used as a lymphodepleting chemotherapy.

DRUG

Fludarabine

Fludarabine will be used as a lymphodepleting chemotherapy.

Trial Locations (38)

10065

Memorial Sloan Kettering cancer center, New York

15232

University of Pittsburgh, Hillman Cancer centre, Pittsburgh

20089

Ircss Istituto Clinico Humanitas, Romano di Lombardia

20133

Fondazione IRCCS Instituto Nazionale Dei Tumori, Milan

23298

Virginia Commonwealth University, Richmond

27710

Duke University Medical Center, Durham

28040

Hospital Universitario Fundación Jiménez Díaz, Madrid

32224

Mayo Clinic Jacksonville, Jacksonville

33604

CHU de Bordeaux GH Sud Hôpital Haut Lévêque, Pessac

37203

Tennessee Oncology, Nashville

41013

Hospital Virgen Del Rocio, Seville

43210

Ohio State University-Columbus, Columbus

48109

University of Michigan Medical Center, Ann Arbor

53226

Froedtert Hospital, Milwaukee

55455

Minnesota Oncology Hematology, Minneapolis

55905

Mayo Clinic Rochester, Rochester

60637

University of Chicago, Chicago

63110

Washington University, St Louis

69373

Centre Léon Bérard, Lyon

80218

Sarah Cannon Research Institute, Denver

84112

University of Utah, Salt Lake City

91010

City of Hope National Medical Center, Duarte

94305

Stanford Hospital and Clinics, Stanford

97239

Oregon Health and Science University, Portland

52242-1009

University of Iowa College of Medicine, Iowa City

02114

Dana Farber Cancer Institute, Boston

Massachusetts General Hospital, Boston

75390-8565

University Of Texas Southwestern Medical Center, Dallas

75390-9063

University of Texas Southwestern Medical Center, Dallas

98109-1024

Fred Hutchinson Cancer Research Center, Seattle

H1T 2M4

CIUSSS de L'Est-De-Lile-De-Montreal, Montreal

M5G 2M9

Princess Margaret Cancer Centre, Toronto

1066 CX

The Netherlands Cancer Institute, Amsterdam

08025

Hospital Santa Creu Y Sant Pau, Barcelona

08907

Ico Duran y Reynals l'Hospitalet de Llobrega, Hospitalet de Llobregat, Barcelona

SW3 6JJ

Royal Marsden Hospital, London

WC1E 6AG

University College Hospital-London, London

M20 4BX

Christie Hospital NHS Foundation Trust, Manchester

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Adaptimmune

INDUSTRY

NCT05993299 - Study to Evaluate Safety and Antitumor Activity of Lete-Cel (GSK3377794) in HLA-A2+ Participants With NY-ESO-1 Positive Previously Untreated Advanced (Metastatic or Unresectable) Synovial Sarcoma and Myxoid/Round Cell Liposarcoma | Biotech Hunter | Biotech Hunter