Low-dose Chidamide Maintenance Therapy After Allo-HSCT for T-cell Acute Lymphoblastic Leukemia or T-cell Lymphomas

PHASE2CompletedINTERVENTIONAL
Enrollment

44

Participants

Timeline

Start Date

July 15, 2023

Primary Completion Date

June 1, 2025

Study Completion Date

July 1, 2025

Conditions
T Lymphoblastic Leukemia/Lymphoma
Interventions
DRUG

Chidamide

In the time window of 30-180 days after transplantation: oral chidamide 10mg twice a week with a total of 96 courses(4 weeks as a course). If the MRD turns positive during treatment, the dose can be increased to a maximum of 20 mg twice a week, and donor lymphocyte infusion (DLI) is also permitted in the case of MRD positivity.

Trial Locations (1)

310006

The First Hospital of Zhejiang Medical Colleage Zhejiang University, Hangzhou

All Listed Sponsors
collaborator

The First Affiliated Hospital of Zhengzhou University

OTHER

collaborator

The Affiliated Hospital of Medical College, Ningbo University

OTHER

lead

Zhejiang University

OTHER