Rapid Research in Diagnostics Development for TB Network (R2D2 Kids) and Assessing Diagnostics At POC for TB in Children (ADAPT for Kids)

NARecruitingINTERVENTIONAL
Enrollment

2,100

Participants

Timeline

Start Date

January 26, 2024

Primary Completion Date

September 1, 2026

Study Completion Date

September 1, 2026

Conditions
TuberculosisDiagnosticsGlobal Health
Interventions
DIAGNOSTIC_TEST

Oral swab molecular testing

Swab-based testing provides a non-invasive approach to collect respiratory specimens for TB testing. Data in adults suggests that swab-based testing could be valuable when sputum collection is not feasible or available.

DIAGNOSTIC_TEST

Automated Cough Sound Analysis

Cough sounds can be collected through a mobile phone and tablet, and then analyzed with machine learning algorithms to predict TB.

DIAGNOSTIC_TEST

Automated Lung Sound Analysis

Lung sounds can be collected with a non-invasive digital stethoscope, and then saved on a tablet or phone and analyzed by machine learning algorithms to predict TB.

OTHER

Chest X Ray Computer Aided Detection

Several artificial intelligence algorithms have been developed to predict TB, though this has not yet been validated in children.

Trial Locations (3)

Unknown

RECRUITING

Instituto Nacional de Saúde, Maputo

NOT_YET_RECRUITING

Dora Nginza Hospital, Cape Town

NOT_YET_RECRUITING

Mulago National Referral Hospital, Kampala

All Listed Sponsors
collaborator

Instituto Nacional de Saúde, Mozambique

OTHER_GOV

collaborator

National Referral Hospital

OTHER_GOV

collaborator

University of Cape Town

OTHER

collaborator

Johns Hopkins University

OTHER

collaborator

Elizabeth Glaser Pediatric AIDS Foundation

OTHER

collaborator

National Institute of Allergy and Infectious Diseases (NIAID)

NIH

collaborator

University of California, Irvine

OTHER

lead

University of California, San Francisco

OTHER