Chronic Hypertension and Pregnancy 2 (CHAP2) Pilot Project

PHASE1RecruitingINTERVENTIONAL
Enrollment

74

Participants

Timeline

Start Date

April 24, 2024

Primary Completion Date

April 30, 2026

Study Completion Date

June 30, 2026

Conditions
Hypertension in Pregnancy
Interventions
DRUG

Labetalol or Nifedipine

The choice of anti-HTN will be based on the patient and provider's experience and preference. First line anti-HTN recommended in pregnancy- labetalol or nifedipine- will be administered to patients. At least weekly, a study team member will review the participants' BPs and, if randomized to intervention and a higher dose is needed to maintain BPs \<130/80 mmHg, the study team member will communicate with the clinical team, led by a University of Alabama Maternal Fetal Medicine Attending, in order to ensure coordination between the research and clinical care teams. Labetalol will be initiated at 200 mg twice daily and escalated in 200mg /dose daily until BP\<130/80mmHg to a maximum dose of 2400mg/day. Procardia will be initiated at 30mg XL once daily and uptitrated in 30mg increments until a maximum dose of 120mg daily. Postpartum, titration will occur in similar fashion. The patient will be transitioned to her primary care provider for BP management after the 6-week postpartum visit.

Trial Locations (1)

35294

RECRUITING

UAB, Birmingham

All Listed Sponsors
lead

University of Alabama at Birmingham

OTHER