The Effects of Successful OSA Treatment on Memory and AD Biomarkers in Older Adults Study

NARecruitingINTERVENTIONAL
Enrollment

200

Participants

Timeline

Start Date

April 22, 2024

Primary Completion Date

June 30, 2027

Study Completion Date

May 31, 2028

Conditions
Obstructive Sleep ApneaCognitive Decline
Interventions
DEVICE

Positive airway pressure

Positive airway pressure (PAP) therapy is a sleep apnea treatment that uses a stream of compressed air to support the airway during sleep. With PAP therapy, a mask is worn during sleep and a portable machine gently blows pressurized room air from into your upper airway through a tube connected to the mask. This positive airflow helps keep the airway open, preventing the collapse that occurs during apnea, thus allowing normal breathing.

DEVICE

Oral appliance therapy

Oral appliance therapy involves the use of a dental appliance or oral mandibular advancement device that prevents the tongue from blocking the throat and/or advances the lower jaw forward. These devices help keep the airway open during sleep.

DEVICE

Positional therapy

A NightShift Sleep Positioner (Advanced Brain Monitoring) is a neck vibration device, FDA approved to treat positional sleep apnea. The device detects patient supine position and delivers a small vibratory signal to the back of the neck to prompt position change.

Trial Locations (4)

10016

RECRUITING

New York University, New York

10023

RECRUITING

Mount Sinai, New York

15213

RECRUITING

University of Pittsburgh, Pittsburgh

85719

RECRUITING

University of Arizona, Tucson

All Listed Sponsors
collaborator

Icahn School of Medicine at Mount Sinai

OTHER

collaborator

New York University

OTHER

collaborator

University of Arizona

OTHER

collaborator

University of Pittsburgh

OTHER

collaborator

National Institute on Aging (NIA)

NIH

lead

California Pacific Medical Center Research Institute

OTHER