Sintilimab+Bevacizumab+TACE vs. Lenvatinib+TACE for Advanced HCC

PHASE3RecruitingINTERVENTIONAL
Enrollment

258

Participants

Timeline

Start Date

August 1, 2023

Primary Completion Date

July 31, 2027

Study Completion Date

July 31, 2027

Conditions
Hepatocellular Carcinoma Non-resectable
Interventions
DRUG

Sin-Bev-TACE

Sintilimab (200mg I.V. q3w) and bevacizumab (7.5mg/kg I.V. q3w) are administered at 3-7 days after the first TACE. The study treatment of sintilimab and bevacizumab will last up to 24 months. TACE can be repeated on demand.

DRUG

Len-TACE

Lenvatinib 12mg (body weight ≥60kg) or 8mg (body weight \<60kg) P.O. qd will be started at 3-7 days after the first TACE. TACE will be repeated on demand.

Trial Locations (1)

510260

RECRUITING

the Second Affiliated Hospital of Guangzhou Medical University, Guangzhou

All Listed Sponsors
collaborator

Affiliated Hospital of Guangdong Medical University

OTHER

collaborator

Zhongshan People's Hospital, Guangdong, China

OTHER

collaborator

Lecong Hospital, Shunde District, Foshan

UNKNOWN

collaborator

First People's Hospital of Foshan

OTHER

collaborator

Affiliated Cancer Hospital & Institute of Guangzhou Medical University

OTHER

lead

Second Affiliated Hospital of Guangzhou Medical University

OTHER