Study of Utidelone Based Neoadjuvant Treatment on Early High-risk or Locally Advanced Breast Cancer

Utidelone injection 30mg/m2, on days 1-5 of each cycle

Carboplatin Area under curve(AUC)6, iv, was administered on day 1

Epirubicin 75mg/m2 was administered on day 1

Trastuzumab 8mg/kg iv in first cycle on day 1, then 6mg/kg in the rest cycles

Pertuzumab 840mg/kg iv in first cycle on day 1, then 420mg/kg in the rest cycles