221
Participants
Start Date
March 1, 2025
Primary Completion Date
May 15, 2027
Study Completion Date
November 1, 2028
FES
16-alpha-18F-fluoro-17-beta-estradiol(FES) is a radiolabeled form of estrogen binding to functionally active ER which will be used as radiotracer for the PET/MRI exam
PET/MRI A
An additional FES PET/MRI will be performed before surgery.
PET/MRI B
Two additional PET/MRI will be performed before and after induction ET.
PET/MRI C
Two additional PET/MRI will be performed before and after two cycles of neoadjuvant chemotherapy.
PET/MRI D
Two additional PET/MRI will be performed before and after two cycles of systemic therapy.
Translational analysis
Selected cases of heterogeneous tumors on imaging will be also investigated on pathology, imaging, genomic and radiomic levels.
IRCCS San Raffaele
OTHER
Università Vita-Salute San Raffaele
OTHER