NCT05981573 - Assessment of Methadone Dose Taken | Biotech Hunter

Enrollment

Participants

Timeline

Start Date

August 26, 2024

Primary Completion Date

March 31, 2026

Study Completion Date

April 30, 2026

Conditions

Methadone ToxicityMethadone OverdosePain, ChronicDrug Metabolism, Poor, CYP2D6-RelatedMetabolism Medication Toxicity

Interventions

DIAGNOSTIC_TEST

Measurement of Methadone in the Interstitial Fluid (ISF) before and after prescribed dose taken ex vivo

Measurement of Methadone and its metabolites in interstitial fluid with Liquid Chromatography - Mass Spectroscopy (LC-MS) and Aptamer based Assay

DRUG

Measurement of Methadone in the Interstitial Fluid before and after prescribed dose taken in vivo

Measurement of Methadone and its metabolites in ISF with LC-MS and RMM

DEVICE

ISF Extraction Device 2

Up to 15 minute periods of continuous ISF collection for analysis

Trial Locations (1)

RECRUITING

Synergy, Lemon Grove