NCT05980689 - Combination of AK104 and Neoadjuvant Chemoradiotherapy in pMMR/MSS Locally Advanced Rectal Cancer | Biotech Hunter

Enrollment

Participants

Timeline

Start Date

October 24, 2023

Primary Completion Date

June 30, 2024

Study Completion Date

January 31, 2025

Conditions

Locally Advanced Rectal Cancer

Interventions

DRUG

AK104

During neo-CRT: 2 cycles of AK104, 10mg/kg d1 q3w. After neo-CRT: 3 cycles of AK104, 10mg/kg d1 q3w.

DRUG

Capecitabine

During neo-CRT: 825mg/m2 bid Monday-Friday per week

RADIATION

Neoadjuvant Radiotherapy

IMRT DT: 50Gy/25Fx

Trial Locations (1)

RECRUITING

Sun Yat-sen University Cancer Center, Guangzhou