30
Participants
Start Date
February 1, 2024
Primary Completion Date
October 1, 2027
Study Completion Date
October 1, 2028
fMRI-EEG-TMS
Participants will undergo a magnetic resonance imaging (MRI) scan with combined electroencephalography (EEG), and single-pulse transcranial magnetic stimulation (TMS) while completing cognitive flexibility (CF) and emotion recognition (CR) tasks.
fNIRS-EEG-TMS
Participants brain activity will be measured using functional near-infrared spectroscopy (fNIRS) with combined electroencephalography (EEG), and single-pulse transcranial magnetic stimulation (TMS) while completing cognitive flexibility (CF) and emotion recognition (CR) tasks.
fNIRS-EEG-rTMS Interleaved with CBT
Participants brain activity will be measured using functional near-infrared spectroscopy (fNIRS) with combined electroencephalography (EEG), and repetitive transcranial magnetic stimulation (rTMS). rTMS will be delivered via a MagVenture MagPro100 and Cool-B65 coil. The investigators will use a standard resting motor threshold (rMT) determination to determine the TMS dose. Treatment will be delivered at 120% of the motor threshold. The accelerated paradigm will consist 6 session a day for 5-6 days. Each rTMS session will be separated by 30 minutes of Cognitive Behavioral Therapy (CBT). rTMS treatment will be delivered at an individualized left DLPFC target based on each participant's individualized scans from prior neuroimaging sessions.
RECRUITING
Medical Univeristy of South Carolina, Charleston
Columbia University
OTHER
University of Oklahoma
OTHER
Defense Advanced Research Projects Agency
FED
University of Wisconsin, Madison
OTHER
Medical University of South Carolina
OTHER