RECOVERS - Realigning Emotion and COgnition Via prEcision Regulation networkS

RecruitingOBSERVATIONAL
Enrollment

30

Participants

Timeline

Start Date

February 1, 2024

Primary Completion Date

October 1, 2027

Study Completion Date

October 1, 2028

Conditions
HealthyDepression - Major Depressive Disorder
Interventions
DEVICE

fMRI-EEG-TMS

Participants will undergo a magnetic resonance imaging (MRI) scan with combined electroencephalography (EEG), and single-pulse transcranial magnetic stimulation (TMS) while completing cognitive flexibility (CF) and emotion recognition (CR) tasks.

DEVICE

fNIRS-EEG-TMS

Participants brain activity will be measured using functional near-infrared spectroscopy (fNIRS) with combined electroencephalography (EEG), and single-pulse transcranial magnetic stimulation (TMS) while completing cognitive flexibility (CF) and emotion recognition (CR) tasks.

DEVICE

fNIRS-EEG-rTMS Interleaved with CBT

Participants brain activity will be measured using functional near-infrared spectroscopy (fNIRS) with combined electroencephalography (EEG), and repetitive transcranial magnetic stimulation (rTMS). rTMS will be delivered via a MagVenture MagPro100 and Cool-B65 coil. The investigators will use a standard resting motor threshold (rMT) determination to determine the TMS dose. Treatment will be delivered at 120% of the motor threshold. The accelerated paradigm will consist 6 session a day for 5-6 days. Each rTMS session will be separated by 30 minutes of Cognitive Behavioral Therapy (CBT). rTMS treatment will be delivered at an individualized left DLPFC target based on each participant's individualized scans from prior neuroimaging sessions.

Trial Locations (1)

29425

RECRUITING

Medical Univeristy of South Carolina, Charleston

All Listed Sponsors
collaborator

Columbia University

OTHER

collaborator

University of Oklahoma

OTHER

collaborator

Defense Advanced Research Projects Agency

FED

collaborator

University of Wisconsin, Madison

OTHER

lead

Medical University of South Carolina

OTHER