A Study to Investigate the Safety and Efficacy of KER-012 in Combination With Background Therapy in Adult Participants With Pulmonary Arterial Hypertension (PAH) (TROPOS Study).

PHASE2CompletedINTERVENTIONAL
Enrollment

113

Participants

Timeline

Start Date

October 17, 2023

Primary Completion Date

March 5, 2025

Study Completion Date

March 11, 2025

Conditions
Pulmonary Arterial Hypertension
Interventions
BIOLOGICAL

Dose A KER-012

Dose A KER-012 (Q4W);

BIOLOGICAL

Dose B KER-012

Dose B KER-012 (Q4W);

BIOLOGICAL

Dose C KER-012

Dose C KER-012 (Q4W);

BIOLOGICAL

Placebo for 24 Weeks followed by Dose B KER-012 for 72 weeks

Treatment Period (24 weeks): Placebo SC (Q4W) Extension Period (72 weeks after Placebo treatment): KER-012 (Dose B) SC (Q4W)

Trial Locations (55)

2010

TROPOS Study Site 800, Darlinghurst

2050

TROPOS Study Site 804, Camperdown

2095

TROPOS Study Site 801, Sydney

2305

TROPOS Study Site 803, New Lambton Heights

3004

TROPOS Study Site 805, Melbourne

4066

TROPOS Study Site 807, Auchenflower

8035

TROPOS Study Site 413, Barcelona

11217

TROPOS Study Site 890, Taipei

21565

TROPOS Study Site 881, Incheon

28041

TROPOS Study Site 410, Madrid

29425

TROPOS Study Site 106, Charleston

30625

TROPOS Study Site 340, Hanover

32224

TROPOS Study Site 108, Jacksonville

35392

TROPOS Study Site 341, Giesen

39008

TROPOS Study Site 412, Barcelona

TROPOS Study Site 411, Santander

40202

TROPOS Study Site 110, Louisville

45221

TROPOS Study Site 113, Cincinnati

63110

TROPOS Study Site 115, St Louis

66160

TROPOS Study Site 100, Kansas City

66424

TROPOS Study Site 344, Homburg

69120

TROPOS Study Site 343, Heidelberg

75390

TROPOS Study Site 112, Dallas

77030

TROPOS Study Site 102, Houston

81362

TROPOS Study Site 891, Kaohsiung City

85258

TROPOS Study Site 111, Scottsdale

85719

TROPOS Study Site 107, Tucson

87106

TROPOS Study Site 114, Albuquerque

89030

TROPOS Study Site 200, Blumenau

90020

TROPOS Study Site 202, Porto Alegre

90502

TROPOS Study Site 105, Torrance

93053

TROPOS Study Site 345, Regensburg

94270

TROPOS Study Site 320, Le Kremlin-Bicêtre

94305

Site PI TROPOS Study Site 104, Stanford

481091

TROPOS Study Site 101, Ann Arbor

02111

TROPOS Study Site 103, Boston

02115

TROPOS Study Site 109, Boston

05403

TROPOS Study Site 201, São Paulo

04103

TROPOS Study Site 342, Leipzig

80-214

TROPOS Study Site 704, Gdansk

31-202

TROPOS Study Site 701, Krakow

91-347

TROPOS Study Site 705, Lodz

05-400

TROPOS Study Site 702, Otwock

60-355

TROPOS Study Site 703, Poznan

61-848

TROPOS Study Site 706, Poznan

2805-267

TROPOS Study Site 403, Almada

3000-075

TROPOS Study Site 402, Coimbra

1769-001

TROPOS Study Site 400, Lisbon

4099-001

TROPOS Study Site 401, Porto

03080

TROPOS Study Site 883, Seoul

03722

TROPOS Study Site 882, Seoul

06351

TROPOS Study Site 880, Seoul

G81 4DY

TROPOS Study Site 441, Glasgow

SW3 6NP

TROPOS Study Site 442, London

W12 0HS

TROPOS Study Site 440, London

Sponsors
All Listed Sponsors
lead

Keros Therapeutics, Inc.

INDUSTRY

NCT05975905 - A Study to Investigate the Safety and Efficacy of KER-012 in Combination With Background Therapy in Adult Participants With Pulmonary Arterial Hypertension (PAH) (TROPOS Study). | Biotech Hunter | Biotech Hunter