MicroEnvironment Tumor Effects of Radiotherapy - Comprehensive Radiobiology Assessment TRial

NARecruitingINTERVENTIONAL
Enrollment

60

Participants

Timeline

Start Date

January 11, 2024

Primary Completion Date

December 31, 2032

Study Completion Date

December 31, 2032

Conditions
Locally Advanced Cervical CarcinomaLocally Advanced Cervical CancerLocally Advanced Pancreas CancerLocally Advanced Pancreatic CarcinomaLocally Advanced Pancreatic CancerCervical CancerPancreas CancerPancreatic CancerCancer of the CervixCancer of the Pancreas
Interventions
OTHER

Tumor collection via biopsy

"Cervical cancer: Pre-radiation therapy, 1 week after beginning radiation therapy, 3 weeks after beginning radiation therapy, and recurrence.~Pancreatic cancer: pre-stereotactic body radiotherapy, 12 weeks after completion of radiotherapy, and recurrence."

OTHER

Blood collection

"Cervical cancer: pre-radiation therapy, 1 week after beginning radiation therapy, 3 weeks after beginning radiation therapy, 6 weeks after completing radiation therapy, 12 weeks after completing radiation therapy, and recurrence.~Pancreatic cancer: pre-stereotactic body radiotherapy, 6 weeks after completion of radiotherapy, 12 weeks after completion of radiotherapy, surgery (if applicable), and recurrence"

DEVICE

Diffusion basis spectrum imaging (DBSI) magnetic resonance imaging (MRI)

"Cervical cancer: initial staging, 12 weeks after completing radiation therapy, and recurrence.~Pancreatic cancer: initial staging, stereotactic body radiotherapy (SBRT) simulation, 12 weeks after completing radiation therapy, and recurrence.~The imaging will be performed when possible."

Trial Locations (1)

63110

RECRUITING

Washington University School of Medicine, St Louis

All Listed Sponsors
collaborator

National Cancer Institute (NCI)

NIH

lead

Washington University School of Medicine

OTHER