A Phase 1/2 Study of AMG 193 in Combination With IDE397 in Participants With Advanced Methylthioadenosine Phosphorylase (MTAP)-Null Solid Tumors

PHASE1/PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

53

Participants

Timeline

Start Date

August 1, 2023

Primary Completion Date

January 5, 2026

Study Completion Date

January 5, 2026

Conditions
MTAP-null Non-Small-Cell Lung CancerMTAP-null Solid Tumors
Interventions
DRUG

AMG 193

Administered PO

DRUG

IDE397

Administered PO

Trial Locations (27)

2100

Rigshospitalet, Copenhagen

3168

Monash Medical Centre, Clayton

5011

The Queen Elizabeth Hospital, Woodville South

10002

National Taiwan University Hospital, Taipei

10016

New York University Grossman School of Medicine and New York University Langone Hospitals, New York

10032

Columbia University Irving Medical Center, New York

10065

Memorial Sloan Kettering Cancer Center, New York

13620

Seoul National University Bundang Hospital, Seongnam-si, Gyeonggi-do

27710

Duke University, Durham

28034

Hospital Universitario Ramon y Cajal, Madrid

29605

Prisma Health Upstate, Greenville

46250

Community Health Network MD Anderson Cancer Center - North, Indianapolis

48109

University of Michigan, Ann Arbor

55102

Health Partners Cancer Center at Regions Hospital, Saint Paul

70403

National Cheng Kung University Hospital, Tainan City

75039

Next Oncology, Irving

77030

University of Texas MD Anderson Cancer Center, Houston

80218

Sarah Cannon Research Institute, Denver

91090

City of Hope National Medical Center, Duarte

02215

Dana Farber Cancer Institute, Boston

08816

Astera Cancer Care, East Brunswick

T6G 1Z2

Cross Cancer Institute, Edmonton

M5G 2M9

Princess Margaret Cancer Centre, Toronto

03080

Seoul National University Hospital, Seoul

03722

Severance Hospital Yonsei University Health System, Seoul

05505

Asan Medical Center, Seoul

08035

Hospital Universitari Vall d Hebron, Barcelona

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Amgen

INDUSTRY