The Effect of a Six Week Intensified Pharmacological Treatment for Major Depressive Disorder Compared to Treatment as Usual in Subjects Who Had a First-time Treatment Failure on Their First-line Treatment.

PHASE3RecruitingINTERVENTIONAL
Enrollment

418

Participants

Timeline

Start Date

August 31, 2024

Primary Completion Date

June 30, 2028

Study Completion Date

June 30, 2028

Conditions
Major Depressive DisorderTreatment Resistant Depression
Interventions
DRUG

Esketamine Nasal Product

See arm description

DRUG

Ketamine Hydrochloride

See arm description

DRUG

Esketamine hydrochloride

See arm description

DRUG

Second-line Antidepressants

See arm description

Trial Locations (12)

11528

NOT_YET_RECRUITING

Eginition Hospital, department of psychiatry, Athens

44287

RECRUITING

LWL-Klinik Dortmund, Bereich Forschung & Wissenschaft, Dortmund

80138

RECRUITING

Università degli studi della Campania Luigi Vanvitelli, Naples

Unknown

RECRUITING

Medical University Innsbruck, Innsbruck

RECRUITING

Universitätsklinik für Psychiatrie und Psychotherapie Bielefeld, Bielefeld

RECRUITING

University Hospital Frankfurt am Main - Goethe University, Frankfurt am Main

RECRUITING

Westfälische Wilhelms-Universität Münster, Münster

NOT_YET_RECRUITING

Universita degli Studi di Brescia, Brescia

RECRUITING

University of Cagliari, Cagliari

NOT_YET_RECRUITING

"Azienda Ospedaliero-Universitaria Città della Salute e della Scienza di Torino", Turin

RECRUITING

Fundació Clínic per a la Recerca Biomèdica, Barcelona

SE5 8AF

NOT_YET_RECRUITING

King's College London, Psychiatry & Cognitive Neuroscience, London

All Listed Sponsors
collaborator

Universität Münster

OTHER

lead

Dr. Inge Winter

OTHER