First-in-human Interleukin-15-transpresenting Wilms' Tumor Protein 1-targeting Autologous Dendritic Cell Vaccination in Cancer Patients

PHASE1/PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

10

Participants

Timeline

Start Date

December 6, 2023

Primary Completion Date

September 28, 2025

Study Completion Date

September 28, 2025

Conditions
Esophageal CancerPancreas CancerOvarian CancerLiver Cancer
Interventions
BIOLOGICAL

IL15-transpresenting WT1-targeted Dendritic Cell Vaccine

IL15/IL15Ra/WT1 DC vaccines (8-10 x 10\^6 cells in 500 μL saline solution with 5% human albumin) will be administered through intradermal injection at 5 sites (100 μL/site) in the ventromedial region of the upper arm (5-10 cm from the axillary lymph nodes). Injection sites will alternate between left and right arms. WT1/DC vaccines are administered every 2 weeks (+- 3 days) for a total of 6 administrations.

Trial Locations (1)

2650

Antwerp University Hospital, Edegem

All Listed Sponsors
collaborator

Kom Op Tegen Kanker

OTHER

collaborator

Stichting tegen Kanker

OTHER

lead

University Hospital, Antwerp

OTHER

NCT05964361 - First-in-human Interleukin-15-transpresenting Wilms' Tumor Protein 1-targeting Autologous Dendritic Cell Vaccination in Cancer Patients | Biotech Hunter | Biotech Hunter