The Effect of a Six Week Intensified Pharmacological Treatment for Schizophrenia Compared to Treatment as Usual in Subjects Who Had a First-time Treatment Failure on Their First-line Treatment.

PHASE4RecruitingINTERVENTIONAL
Enrollment

418

Participants

Timeline

Start Date

August 1, 2024

Primary Completion Date

June 30, 2028

Study Completion Date

June 30, 2028

Conditions
Schizophrenia and Related DisordersEarly Treatment-Resistance
Interventions
DRUG

Clozapine

Participants are randomized to clozapine or second-line antipsychotics. When randomised to clozapine, they will receive clozapine for six weeks.

DRUG

Second-line Antipsychotics (treatment as usual)

Participants are randomized to clozapine or second-line antipsychotics. When randomized to second-line antipsychotics, this means participants will receive treatment as usual. The physician has the choice to administer any second-line antipsychotic. More specification is not possible, as this is a choice the physician makes with the participant based on the characteristic and preference of the participant (in line with standard clinical practice).

Trial Locations (13)

44287

RECRUITING

LWL-Klinik Dortmund, Bereich Forschung & Wissenschaft, Dortmund

80138

RECRUITING

Università degli studi della Campania Luigi Vanvitelli, Naples

86156

NOT_YET_RECRUITING

Bezirkskliniken Schwaben, Bezirkskrankenhaus Augsburg, Augsburg

Unknown

RECRUITING

Medical University Innsbruck, Innsbruck

RECRUITING

Universitätsklinik für Psychiatrie und Psychotherapie Bielefeld, Bielefeld

RECRUITING

University Hospital Frankfurt am Main - Goethe University, Frankfurt am Main

RECRUITING

Klinik für Psychiatrie und Psychotherapie der Universitätsmedizin Mainz, Mainz

RECRUITING

Westfälische Wilhelms-Universität Münster, Münster

RECRUITING

Universita degli Studi di Brescia, Brescia

RECRUITING

University of Cagliari, Cagliari

RECRUITING

"Azienda Ospedaliero-Universitaria Città della Salute e della Scienza di Torino", Turin

RECRUITING

Fundació Clínic per a la Recerca Biomèdica, Barcelona

SE5 8AF

RECRUITING

King's College London, Psychiatry & Cognitive Neuroscience, London

All Listed Sponsors
collaborator

Universität Münster

OTHER

lead

Dr. Inge Winter

OTHER