NCT05958342View on ClinicalTrials.gov

CAlcium and VAsopressin Following Injury Early Resuscitation (CAVALIER) Trial

PHASE2RecruitingINTERVENTIONAL
Enrollment

1,050

Participants

Timeline

Start Date

June 30, 2024

Primary Completion Date

March 31, 2027

Study Completion Date

March 31, 2028

Conditions
TraumaHemorrhage
Interventions
DRUG

Calcium Gluconate

1 gram calcium gluconate provided via intravenous or intraosseous access over approximately 2-5 minutes

DRUG

Vasopressin

4 unit vasopressin bolus followed by vasopressin infusion at 0.04 U/min for eight hours

DRUG

saline placebo

saline placebo volume matched to prehospital or in hospital phase

Trial Locations (7)

15212

RECRUITING

Allegheny Health Network, Pittsburgh

15213

RECRUITING

University of Pittsburgh, Pittsburgh

33136

RECRUITING

University of Miami, Miami

55415

RECRUITING

Hennepin County Medical Center, Minneapolis

80204

RECRUITING

Denver Health Medical Center, Denver

85724

RECRUITING

University of Arizona, Tucson

94110

RECRUITING

Zuckerberg San Francisco General Hospital and Trauma Center at University of California, San Francisco, San Francisco

All Listed Sponsors
collaborator

United States Department of Defense

FED

lead

Jason Sperry

OTHER