A Study of Venetoclax in Combination With Conventional Chemotherapy in Pediatric Patients With Acute Myeloid Leukemia

Venetoclax will be given with each course of therapy. Patients with low-risk AML will receive four courses of therapy, intermediate-risk patients will receive five courses of therapy, and high-risk patients will receive two or three courses of therapy followed by hematopoietic stem cell transplantation.

Given IV over 30 minutes on days 1-5

Given IV over 30 minutes q12 hours on days 1-8 (16 doses)

Given IV

IV over 1 hour on days 1, 3, and 5

Given IV over 30 minutes on days 1-5

Given IV over 15 minutes on days 3-5

IV over 1 hour on days 2-4

Given IV over 1 hour on days 1-5

PO on days 8-28 (21 doses)