A Study of Enlicitide Decanoate (MK-0616 Oral PCSK9 Inhibitor) in Adults With Hypercholesterolemia (MK-0616-013) CORALreef Lipids

PHASE3CompletedINTERVENTIONAL
Enrollment

2,912

Participants

Timeline

Start Date

August 10, 2023

Primary Completion Date

July 28, 2025

Study Completion Date

July 28, 2025

Conditions
HypercholesterolemiaFamilial Hypercholesterolemia
Interventions
DRUG

Enlicitide Decanoate

Oral tablet

DRUG

Placebo

Oral tablet

Trial Locations (168)

110

Taipei Medical University Hospital-Cardiology ( Site 3108), Taipei

112

Taipei Veterans General Hospital ( Site 3106), Taipei

704

National Cheng Kung University Hospital ( Site 3107), Tainan City

1818

Soweto Clinical Trials Centre ( Site 2242), Johannesburg

2193

Charlotte Maxeke Johannesburg Academic Hospital-WCR-LIPIDS ( Site 2241), Johannesburg

7500

TREAD Research ( Site 2253), Cape Town

7530

Tiervlei Trial Centre-Clinical ( Site 2246), Bellville, Cape Town

7925

University of Cape Town (UCT)-Medicine, Division of Lipidology ( Site 2259), Cape Town

9301

IATROS INTERNATIONAL ( Site 2247), Bloemfontein

10002

National Taiwan University Hospital ( Site 3100), Taipei

10029

Icahn School of Medicine at Mount Sinai-Cardiology ( Site 0002), New York

10126

Azienda Ospedaliero-Universitaria Città della Salute e della Scienza di Torino ( Site 1801), Turin

10787

Velocity Clinical Research GmbH Berlin ( Site 1502), Berlin

12203

Charite Universitätsmedizin Berlin Campus Benjamin Franklin ( Site 1533), Berlin

13057

Velocity Clinical Research, Syracuse ( Site 0021), East Syracuse

13620

Seoul National University Bundang Hospital ( Site 3005), Seongnam

14080

Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran ( Site 1071), Mexico City

15001

Hospital Abente y Lago ( Site 2356), A Coruña

15706

CHUS - Hospital Clinico Universitario-Cardiology - Clinical Research Unit ( Site 2320), Santiago de Compostela

16499

Ajou University Hospital ( Site 3006), Suwon

16635

altoona center for clinical research ( Site 0089), Duncansville

19067

Cardiology Consultants of Philadelphia Yardley ( Site 0097), Yardley

20009

Emerson Clinical Research Institute ( Site 0118), Washington D.C.

20110

Manassas Clinical Research Center ( Site 0007), Manassas

20138

Centro Cardiologico Monzino ( Site 1804), Milan

20162

ASST Grande Ospedale Metropolitano Niguarda-Unità Ricerche Cliniche della Cardiologia 4 ( Site 1811), Milan

20854

Velocity Clinical Research Rockville ( Site 0082), Rockville

23294

National Clinical Research, Inc ( Site 0061), Richmond

23435

Centricity Research Suffolk Family Medicine ( Site 0092), Suffolk

23502

Alliance for Multispecialty Research, LLC ( Site 0101), Norfolk

23606

Health Research of Hampton Roads, Inc. ( Site 0044), Newport News

26426

Wonju Severance Christian Hospital ( Site 3008), Wŏnju

26480

Eskisehir Osmangazi University-Cardiology ( Site 2510), Eskişehir

28041

Hospital Universitario 12 de Octubre-Internal Medicine. Unidad de Ensayos Clínicos ( Site 2319), Madrid

28223

HOSPITAL UNIVERSITARIO QUIRONSALUD MADRID-Endocrinologia y Nutrición ( Site 2344), Pozuelo de Alarcón

28644

Chungbuk National University Hospital ( Site 3011), Cheongju-si

28922

Hospital Universitario Fundacion ALcorcon-Endocrinologia y Nutrición ( Site 2316), Alcorcón

29405

Coastal Carolina Research Center ( Site 0006), North Charleston

29615

Velocity Clinical Research, Greenville ( Site 0023), Greenville

29707

Piedmont Research Partners ( Site 0090), Fort Mill

31210

East Coast Institute for Research, LLC ( Site 0033), Macon

32216

Jacksonville Center for Clinical Research ( Site 0049), Jacksonville

33009

Velocity Clinical Research, Hallandale Beach ( Site 0018), Hallandale

33027

South Broward Research ( Site 0051), Miramar

33134

Alliance for Multispecialty Research, LLC ( Site 0088), Coral Gables

33434

Excel Medical Clinical Trials ( Site 0053), Boca Raton

33607

Clinical Research Trials of Florida ( Site 0063), Tampa

33912

Alliance for Multispecialty Research, LLC ( Site 0094), Fort Myers

35100

Ege Universitesi Hastanesi-Cardilogy Department ( Site 2502), Bornova

36526

Alliance for Multispecialty Research, LLC ( Site 0093), Daphne

36535

G&L Research ( Site 0043), Foley

37660

Holston Medical Group ( Site 0048), Kingsport

37920

Alliance for Multispecialty Research, LLC ( Site 0008), Knoxville

39503

Velocity Clinical Research, Gulfport ( Site 0039), Gulfport

40213

L-MARC Research Center ( Site 0001), Louisville

40509

Alliance for Multispecialty Research, LLC ( Site 0028), Lexington

41009

Hospital Universitario Virgen Macarena ( Site 2352), Seville

41380

Kocaeli Üniversitesi-Cardiology ( Site 2516), Kocaeli

41950

Vithas Hospital Sevilla-Unidad de Salud Metabólica. Diabetes y Obesidad ( Site 2349), Castilleja de la Cuesta

42601

Keimyung University Dongsan Hospital CRC room 1 ( Site 3003), Daegu

44600

Instituto Jalisciense de Investigacion en Diabetes y Obesidad-Endocrinology ( Site 1057), Guadalajara

45359

Unterfrintroper Hausarztzentrum Klinische Forschung ( Site 1542), Essen

46010

HOSPITAL CLINICO DE VALENCIA-CARDIOLOGY ( Site 2321), Valencia

46260

Midwest Institute For Clinical Research ( Site 0059), Indianapolis

47714

Synexus Clinical Research US, Inc. ( Site 0109), Evansville

48108

Inje University Haeundae Paik Hospital ( Site 3010), Haeundae-gu

49201

Dong-A University Hospital ( Site 3013), Busan

49241

Pusan National University Hospital-Internal Medicine ( Site 3012), Busan

50006

Changhua Christian Hospital ( Site 3101), Changhua

57701

Monument Health Clinical Research, a department of Monument -Monument Health Clinical Research, a d ( Site 0009), Rapid City

58104

Lillestol Research ( Site 0026), Fargo

60422

Healthcare Research Network - Chicago ( Site 0052), Flossmoor

61469

Chonnam National University Hospital ( Site 3014), Gwangju

63042

Healthcare Research Network - St. Louis ( Site 0054), Hazelwood

70433

Velocity Clinical Research, Covington ( Site 0068), Covington

71004

Chi Mei Medical Center-Cardiology ( Site 3104), Tainan City

75230

Velocity Clinical Research, Dallas ( Site 0114), Dallas

77030

Center for Cardiometabolic Disease Prevention/Baylor College of Medicine ( Site 0111), Houston

78229

Clinical Trials of Texas, LLC ( Site 0103), San Antonio

83301

Chang Gung Memorial Hospital at Kaohsiung ( Site 3102), Kaohsiung City

84088

Velocity Clinical Research, Salt Lake City ( Site 0019), West Jordan

84106

Synexus Clinical Research US, Inc. ( Site 0110), Salt Lake City

85020

Synexus Clinical Research US, Inc.-Synexus Clinical Research US, Inc - Central Phoenix ( Site 0084), Phoenix

87106

New Mexico Clinical Research & Osteoporosis Center ( Site 0005), Albuquerque

89106

Jubilee Clinical Research ( Site 0106), Las Vegas

89119

AB Clinical Trials ( Site 0070), Las Vegas

90211

National Heart Institute-Research ( Site 0087), Beverly Hills

92408

Velocity Clinical Research, Banning ( Site 0017), San Bernardino

95122

Azienda Ospedaliera Garibaldi ( Site 1810), Catania

95821

Clinical Trials Research ( Site 0115), Sacramento

98057

Rainier Clinical Research Center ( Site 0116), Renton

99437

Zentralklinik Bad Berka ( Site 1530), Bad Berka

100029

Beijing Anzhen Hospital, Capital Medical University-Cardiovascular ( Site 3300), Beijing

100050

Beijing Friendship Hospital Affiliate of Capital University-Cardiology ( Site 3303), Beijing

110231

Salud SURA Calle 100 ( Site 0918), Bogotá

136000

Siping Central People's Hospital-Cardiovascular Department ( Site 3311), Siping

213000

Changzhou Second People's Hospital-Cardiology ( Site 3373), Changzhou

225001

Northern Jiangsu People's Hospital ( Site 3308), Yangzhou

250252

Healthy Medical Center S.A.S ( Site 0913), Zipaquirá

323000

People's Hospital of Lishui City-department of cardiovascular ( Site 3302), Lishui

330003

The Third Hospital of Nanchang - Fuhe-cardiology ( Site 3378), Nanchang

380280

Erciyes Universitesi Tıp Fakultesi Hastaneleri-endocrine ( Site 2522), Kayseri

400072

The Second Affiliated Hospital of Chongqing Medical University ( Site 3320), Chongqing

404000

Chongqing University Three Gorges Hospital ( Site 3321), Chongqing

410005

Hunan Provincial People's Hospital-Cardiology ( Site 3317), Changsha

430030

Wuhan Fourth Hospital ( Site 3356), Wuhan

434036

Jingzhou Central Hospital-Cardiology ( Site 3376), Jingzhou

510080

Guangdong Provincial People's Hospital-Cardiology ( Site 3304), Guangzhou

510280

Zhujiang Hospital of Southern Medical University ( Site 3329), Guangzhou

516001

Huizhou Municipal Central Hospital ( Site 3379), Huizhou

518053

The University of Hong Kong-Shenzhen Hospital-Cardiovascular department ( Site 3318), Shenzhen

610021

Chengdu Second Municipal People's Hospital ( Site 3332), Chengdu

712000

Xianyang Hospital of Yan'an University ( Site 3340), Xianyang

760032

Fundación Valle del Lili ( Site 0904), Santiago de Cali

3109601

Rambam Health Care Campus-internal department ( Site 1718), Haifa

3810101

Hillel Yaffe Medical Center ( Site 1705), Hadera

4428164

Meir Medical Center. ( Site 1714), Kfar Saba

5265601

Sheba Medical Center ( Site 1708), Ramat Gan

7033001

Yitzhak Shamir Medical Center. ( Site 1712), Ẕerifin

9103102

Shaare Zedek Medical Center ( Site 1710), Jerusalem

9112001

Hadassah Medical Center ( Site 1706), Jerusalem

Hadassah Medical Center ( Site 1709), Jerusalem

C1060ABN

CEDIC ( Site 0612), CABA

B7600FZO

Instituto de Investigaciones Clínicas Mar del Plata ( Site 0605), Mar del Plata

B2800DGH

Instituto de Investigaciones Clinicas Zarate ( Site 0600), Zárate

C1425AGC

Centro Medico Dra. Laura Maffei- Investigacion Clinica Aplicada ( Site 0604), Buenos Aires

C1426ABP

Fundación Respirar ( Site 0610), Buenos Aires

C1056ABI

Centro de Investigaciones Metabólicas (CINME)-Cardiology ( Site 0620), CABA

050021

Fundación Centro de Investigación Clínica CIC ( Site 0906), Medellín

08001

Ciensalud Ips S A S ( Site 0903), Barranquilla

080020

Clinica de la Costa S.A.S. ( Site 0902), Barranquilla

01307

Universitaetsklinikum Carl Gustav Carus Dresden-Universitätsstudienzentrum für Stoffwechselerkranku ( Site 1508), Dresden

06679

Hausarzt- und Diabetologische Schwerpunktpraxis Hohenmölsen - Weiβenfels ( Site 1527), Hohenmölsen

4941 492

Rabin Medical Center ( Site 1720), Petah Tikva

00133

Fondazione Policlinico Tor Vergata ( Site 1809), Rome

00189

Azienda Ospedaliera Sant'Andrea-Department of Clinical and Molecular Medicine ( Site 1807), Rome

807-0857

Hirohata Naika Clinic ( Site 3513), Kitakyusyu-shi

311-0113

Nakakinen clinic ( Site 3510), Naka

300-1207

Noritake Clinic ( Site 3512), Ushiku

920-8650

National Hospital Organization Kanazawa Medical Center ( Site 3508), Kanazawa

020-0132

Hirano Medical Clinic ( Site 3522), Morioka

981-3133

Shirai Healthcare Clinic Izumichuou ( Site 3527), Sendai

598-8577

Rinku General Medical Center ( Site 3503), Izumisano

582-0005

Shiraiwa Medical Clinic ( Site 3514), Kashihara

565-0853

Medical Corporation Heishinkai OCROM Clinic ( Site 3501), Suita-shi

350-0495

Saitama Medical University Hospital ( Site 3506), Iruma

113-0033

Teramoto Medical and Dental Clinic ( Site 3507), Bunkyo-ku

103-0027

Tokyo-Eki Center-building Clinic ( Site 3505), Chuo-ku

104-0031

Fukuwa Clinic ( Site 3504), Chuo-ku

173-8606

Teikyo University Hospital ( Site 3500), Itabashi-ku

125-0054

Kato Clinic of Internal Medicine ( Site 3509), Katsushika-ku

181-0013

Kanno Naika ( Site 3511), Mitaka

177-0041

Sugawara Clinic ( Site 3519), Nerima-ku

144-0051

Shin Clinic ( Site 3517), Ōta-ku

160-0008

Medical Corporation Heishinkai ToCROM Clinic ( Site 3502), Shinjuku-ku

160-0023

Mitsukoshi Health and Welfare Foundation ( Site 3521), Shinjuku-ku

810-0001

Medical Corporation Hakuaikai Wellness Tenjin Clinic ( Site 3520), Fukuoka

730-8518

Hiroshima City Hiroshima Citizens Hospital ( Site 3518), Hiroshima

153-0051

Mishuku Hospital ( Site 3524), Tokyo

03080

Seoul National University Hospital ( Site 3001), Seoul

03181

Kangbuk Samsung Hospital ( Site 3009), Seoul

03722

Severance Hospital, Yonsei University Health System ( Site 3002), Seoul

05505

Asan Medical Center ( Site 3004), Seoul

06351

Samsung Medical Center-cardiology ( Site 3000), Seoul

06591

The Catholic Univ. of Korea Seoul St. Mary's Hospital-cardiology ( Site 3007), Seoul

08500

EBA CENTELLES ( Site 2311), Centelles

06230

Hacettepe Universite Hastaneleri ( Site 2500), Altindağ

06800

Ankara Bilkent Şehir Hastanesi-cardiology ( Site 2501), Ankara

All Listed Sponsors
lead

Merck Sharp & Dohme LLC

INDUSTRY