A Study to Assess Safety and Efficacy of CHO-H01 As a Single Agent/Combined with Lenalidomide in Subjects with Refractory or Relapsed Non-Hodgkin's Lymphoma

PHASE1/PHASE2RecruitingINTERVENTIONAL
Enrollment

37

Participants

Timeline

Start Date

January 15, 2020

Primary Completion Date

December 23, 2026

Study Completion Date

December 23, 2026

Conditions
Non-Hodgkin Lymphoma
Interventions
DRUG

CHO-H01

"Phase 1:~Subjects will be administered intravenous (IV) infusion of assigned dose level of CHO-H01, once a week for 4 weeks (Cycle 1-28-Day cycle).~From Cycle 2 onwards, on Day 1 of each subsequent 21-day cycle until disease progression (or a total of 6 cycles \[19 weeks\] of study)."

DRUG

CHO-H01 at RP2D

"Subjects will be administered intravenous (IV) infusion of RP2D level of CHO-H01, once a week for 4 weeks (Cycle 1-28-Day cycle).~From Cycle 2 onwards, on Day 1 of each subsequent 28-day cycle until disease progression (or a total of 6 cycles \[19 weeks\] of study)."

DRUG

Lenalidomide

Subjects will receive oral lenalidomide 20 mg once daily from Day 1 to Day 21 per 28-day cycle.

Trial Locations (8)

100

RECRUITING

National Taiwan University Hospital - Hematology And Oncology, Taipei

404

RECRUITING

China Medical University Hospital - Hematology/Oncology - Taichung, Taichung

833

RECRUITING

Chang Gung Medical Foundation - Kaohsiung Chang Gung Memorial Hospital - Hemato-Oncology, Kaohsiung City

11490

RECRUITING

Tri-Service General Hospital - Neihu Branch - Hematology, Taipei

23561

RECRUITING

Taipei Medical University - Shuang Ho Hospital - Oncology, New Taipei City

33305

TERMINATED

Chang Gung Medical Foundation - LinKou Chang Gung Memorial Hospital - Hematology and Oncology - Hematology and Oncology, Taoyuan District

70403

RECRUITING

National Cheng Kung University Hospital - Internal Medicine, Tainan City

77389

WITHDRAWN

Renovatio Clinical, The Woodlands

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Cho Pharma Inc.

INDUSTRY

NCT05950165 - A Study to Assess Safety and Efficacy of CHO-H01 As a Single Agent/Combined with Lenalidomide in Subjects with Refractory or Relapsed Non-Hodgkin's Lymphoma | Biotech Hunter | Biotech Hunter