Study of Cryoablation and Nirogacestat for Desmoid Tumor

Nirogacestat 150 mg by mouth twice-daily continuously for Cycles 1 through 3. Treatment with nirogacestat may continue via this study protocol for up to 24 months (26 cycles of treatment), unless there is progression of disease, intolerance, start of new anticancer therapy, or Subject Study Completion or Termination occurs.

Cryoablation procedure (single session) of one tumor mass between Cycles 3 and 4 of nirogacestat treatment