Alpelisib in Pediatric and Adult Patients With Lymphatic Malformations Associated With a PIK3CA Mutation.

PHASE2/PHASE3RecruitingINTERVENTIONAL
Enrollment

232

Participants

Timeline

Start Date

November 24, 2023

Primary Completion Date

September 22, 2028

Study Completion Date

May 2, 2033

Conditions
Lymphatic Malformations
Interventions
DRUG

Alpelisib

"In Stage 1: adult participants (≥18 years of age) will receive dose 1 or dose 2 of alpelisib; pediatric participants (6-17 years of age) will receive dose 2 or dose 3 of alpelisib.~In Stage 2: Adult participants will receive alpelisib at the dose selected for confirmatory phase in adult participants; pediatric participants (6-17 years of age) will will receive alpelisib at the dose selected for confirmatory phase in pediatric participants; and pediatric participants of 0-5 years of age will receive dose 3 of alpelisib"

DRUG

Placebo

In Stage 2, participants will receive matching placebo for 24 weeks of the study

Trial Locations (40)

1200

RECRUITING

Novartis Investigative Site, Brussels

2010

RECRUITING

Novartis Investigative Site, Darlinghurst

2031

RECRUITING

Novartis Investigative Site, Randwick

4101

RECRUITING

Novartis Investigative Site, Brisbane

13885

RECRUITING

Novartis Investigative Site, Marseille

14033

RECRUITING

Novartis Investigative Site, Caen

15006

RECRUITING

Novartis Investigative Site, A Coruña

19104

RECRUITING

CHOP Abramson Pediatric Resch Ctr, Philadelphia

20122

RECRUITING

Novartis Investigative Site, Milan

21034

RECRUITING

Novartis Investigative Site, Dijon

28009

RECRUITING

Novartis Investigative Site, Madrid

28046

RECRUITING

Novartis Investigative Site, Madrid

31400

RECRUITING

Novartis Investigative Site, Toulouse

33076

RECRUITING

Novartis Investigative Site, Bordeaux

34295

RECRUITING

Novartis Investigative Site, Montpellier

37044

RECRUITING

Novartis Investigative Site, Tours

40138

RECRUITING

Novartis Investigative Site, Bologna

44106

RECRUITING

UHO Cleveland Or Ireland Canc Ct, Cleveland

50937

RECRUITING

Novartis Investigative Site, Cologne

59000

RECRUITING

Novartis Investigative Site, Lille

63110

RECRUITING

WA Uni School Of Med, St Louis

68305

RECRUITING

Novartis Investigative Site, Mannheim

69677

RECRUITING

Novartis Investigative Site, Bron

75010

RECRUITING

Novartis Investigative Site, Paris

75015

RECRUITING

Novartis Investigative Site, Paris

77030

RECRUITING

Baylor College Of Medicine, Houston

RECRUITING

U of TX Health Science Ct, Houston

79106

RECRUITING

Novartis Investigative Site, Freiburg im Breisgau

80122

RECRUITING

Novartis Investigative Site, Napoli

94304

RECRUITING

Lucile Packard Childrens Hosp, Palo Alto

94609

RECRUITING

UCSF Benioff Children s Hospital, Oakland

97239

RECRUITING

Oregon Health Science University, Portland

98105

RECRUITING

Childrens Hospital and Regional Medical Center, Seattle

20010-2970

RECRUITING

Childrens National Medical Center, Washington D.C.

02115

RECRUITING

Childrens Hosp Boston Dept of Heme, Boston

45229-3039

RECRUITING

Cinn Children Hosp Medical Center, Cincinnati

04103

RECRUITING

Novartis Investigative Site, Leipzig

00165

RECRUITING

Novartis Investigative Site, Roma

00168

RECRUITING

Novartis Investigative Site, Roma

08950

RECRUITING

Novartis Investigative Site, Esplugues de Llobregat

Sponsors
All Listed Sponsors
lead

Novartis Pharmaceuticals

INDUSTRY